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    NTM neurotrimin [ Homo sapiens (human) ]

    Gene ID: 50863, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NTMprovided by HGNC
    Official Full Name
    neurotriminprovided by HGNC
    Primary source
    HGNC:HGNC:17941
    See related
    Ensembl:ENSG00000182667 MIM:607938; AllianceGenome:HGNC:17941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNT; NTRI; CEPU-1; IGLON2
    Summary
    This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Biased expression in brain (RPKM 12.0), lung (RPKM 3.5) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NTM in Genome Data Viewer
    Location:
    11q25
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (131370615..132336822)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (131406501..132375341)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (131240510..132206716)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131091329-131091830 Neighboring gene NANOG hESC enhancer GRCh37_chr11:131092980-131093481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131105841-131106494 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:131115943-131116588 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:131122872-131123374 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:131123375-131123875 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:131124378-131124878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:131130939-131131476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:131130399-131130938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:131126385-131126884 Neighboring gene uncharacterized LOC124902794 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:131211673-131212872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131243973-131244635 Neighboring gene RNA, U6atac small nuclear 12, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131317907-131318407 Neighboring gene Sharpr-MPRA regulatory region 1894 Neighboring gene uncharacterized LOC101929653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131454209-131455006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:131533266-131533822 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:131540246-131540746 Neighboring gene Sharpr-MPRA regulatory region 15285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:131547556-131548159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131551806-131552306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131552307-131552807 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:131550487-131550986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:131549985-131550486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:131560563-131561086 Neighboring gene GPN-loop GTPase 1 pseudogene Neighboring gene NTM antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131707168-131707668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131707669-131708169 Neighboring gene Sharpr-MPRA regulatory region 14910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131738361-131738886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131735724-131736230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:131737835-131738360 Neighboring gene uncharacterized LOC107984413 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:131758747-131759640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4084 Neighboring gene Sharpr-MPRA regulatory region 6145 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:131801564-131801730 Neighboring gene NANOG hESC enhancer GRCh37_chr11:131824673-131825174 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:131847321-131847831 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:131851053-131852006 Neighboring gene VISTA enhancer hs335 Neighboring gene uncharacterized LOC124902795 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:131958013-131959212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5761 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:131992888-131993886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132115578-132116078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132154772-132155340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132154202-132154771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5764 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132188093-132189292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132199915-132200414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132204500-132205000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5765 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:132324306-132324486 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132340747-132341946 Neighboring gene NTM intronic transcript Neighboring gene uncharacterized LOC124902819 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:132483305-132484504 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:132502505-132503704 Neighboring gene opioid binding protein/cell adhesion molecule like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132513245-132513744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132551286-132551786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132551787-132552287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132755960-132756466 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:132780259-132781458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:132789928-132790505 Neighboring gene uncharacterized LOC105369580

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The cloning and preliminarily functional analysis of the human neurotrimin gene. Liu J, et al. Sci China C Life Sci, 2004 Apr. PMID 15379248
    2. Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma. Parikh TP, et al. Fertil Steril, 2020 Jan. PMID 32033718
    3. A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm. Luukkonen TM, et al. J Med Genet, 2012 Oct. PMID 23054244, Free PMC Article
    4. 11q24.2-25 micro-rearrangements in autism spectrum disorders: Relation to brain structures. Maruani A, et al. Am J Med Genet A, 2015 Dec. PMID 26334118
    5. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Sellar GC, et al. Nat Genet, 2003 Jul. PMID 12819783

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
      Title: Highly Conserved Molecular Features in IgLONs Contrast Their Distinct Structural and Biological Outcomes.
    2. Neurotrimin, a neural cell adhesion molecule, is increased in leiomyoma compared to myometrium in patient tissue after estrogen and progesterone treatment.
      Title: Steroid hormones and hormone antagonists regulate the neural marker neurotrimin in uterine leiomyoma.
    3. NTM is not a susceptibility gene for autism spectrum disorders.
      Title: 11q24.2-25 micro-rearrangements in autism spectrum disorders: Relation to brain structures.
    4. Both the AFF3 and NTM triglyceride associations were replicated among Multi-ethnic Study of Atherosclerosis study participants (P = 1.00 x 10(-7) and 8.00 x 10(-5), respectively).
      Title: Genome-wide linkage and positional association analyses identify associations of novel AFF3 and NTM genes with triglycerides: the GenSalt study.
    5. The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice.
      Title: Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects.
    6. A translocation breaks intron 1 of a splicing isoform of Neurotrimin at 11q25 in a family with intracranial and thoracic aortic aneurysm.
      Title: A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm.
    7. A quantitative analysis of central corneal thickness and a subsequent analysis of primary open-angle glaucoma (POAG), SNPs in two cell adhesion molecules, NTM and CNTNAP4, were identified and may increase POAG susceptibility in a subset of cases.
      Title: Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia.
    8. The finding of this study provided evidence that NTM at 11q25 chromosome regions affecting IQ.
      Title: NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: NTM and NR3C2 polymorphisms influencing intelligence: family-based association studies.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    EBI GWAS Catalog
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    EBI GWAS Catalog
    Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
    EBI GWAS Catalog
    Genome-wide association study identifies candidate genes for male fertility traits in humans.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Variants in several genomic regions associated with asperger disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC60329

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron recognition TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neurotrimin
    Names
    IgLON family member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048209.2 → NP_001041674.1  neurotrimin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001041674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and in the coding region compared to variant 3, resulting in a protein that maintains the reading frame but is shorter and has a distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AA854425, AP004248, AY358331, BE504685
      Consensus CDS
      CCDS41733.1
      UniProtKB/TrEMBL
      B7Z9J9
      Related
      ENSP00000363923.3, ENST00000374791.7
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    2. NM_001144058.2 → NP_001137530.1  neurotrimin isoform 3 precursor

      See identical proteins and their annotated locations for NP_001137530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AP000844, AP004248, AP005155
      Consensus CDS
      CCDS44777.1
      UniProtKB/TrEMBL
      B7Z9J9
      Related
      ENSP00000396722.2, ENST00000425719.6
      Conserved Domains (3) summary
      smart00409
      Location:233 → 310
      IG; Immunoglobulin
      pfam13927
      Location:136 → 205
      Ig_3; Immunoglobulin domain
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    3. NM_001144059.3 → NP_001137531.1  neurotrimin isoform 4 precursor

      See identical proteins and their annotated locations for NP_001137531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR compared to variant 3. The resulting protein (isoform 4) has a distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      AP000844, AP004248, AP005155
      Consensus CDS
      CCDS44778.1
      UniProtKB/TrEMBL
      B7Z1H3
      Related
      ENSP00000363916.1, ENST00000374784.5
      Conserved Domains (3) summary
      smart00409
      Location:233 → 310
      IG; Immunoglobulin
      pfam13927
      Location:136 → 205
      Ig_3; Immunoglobulin domain
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    4. NM_001352001.2 → NP_001338930.1  neurotrimin isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 33, encodes isoform 5.
      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z9J9
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    5. NM_001352002.2 → NP_001338931.1  neurotrimin isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z9J9
      Conserved Domains (3) summary
      smart00409
      Location:233 → 310
      IG; Immunoglobulin
      pfam13927
      Location:136 → 205
      Ig_3; Immunoglobulin domain
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    6. NM_001352003.2 → NP_001338932.1  neurotrimin isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z9J9
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    7. NM_001352004.2 → NP_001338933.1  neurotrimin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      smart00409
      Location:233 → 310
      IG; Immunoglobulin
      pfam13927
      Location:136 → 205
      Ig_3; Immunoglobulin domain
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    8. NM_001352005.2 → NP_001338934.1  neurotrimin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      Consensus CDS
      CCDS91626.1
      UniProtKB/TrEMBL
      B7Z1Z5, B7Z9J9
      Related
      ENSP00000507313.1, ENST00000683400.1
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    9. NM_001352006.2 → NP_001338935.1  neurotrimin isoform 10

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1I4, B7Z9J9
      Conserved Domains (3) summary
      smart00409
      Location:224 → 301
      IG; Immunoglobulin
      pfam13927
      Location:127 → 196
      Ig_3; Immunoglobulin domain
      cl11960
      Location:35 → 123
      Ig; Immunoglobulin domain

    10. NM_001352007.2 → NP_001338936.1  neurotrimin isoform 11

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      smart00409
      Location:224 → 301
      IG; Immunoglobulin
      pfam13927
      Location:127 → 196
      Ig_3; Immunoglobulin domain
      cl11960
      Location:35 → 123
      Ig; Immunoglobulin domain

    11. NM_001352008.2 → NP_001338937.1  neurotrimin isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:203 → 280
      Ig_3; Immunoglobulin domain
      cd00096
      Location:204 → 210
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:25 → 113
      Ig; Immunoglobulin domain

    12. NM_001352009.2 → NP_001338938.1  neurotrimin isoform 13

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    13. NM_001386964.1 → NP_001373893.1  neurotrimin isoform 14

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:208 → 285
      Ig_3; Immunoglobulin domain
      cd00096
      Location:209 → 215
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 118
      Ig; Immunoglobulin domain

    14. NM_001386965.1 → NP_001373894.1  neurotrimin isoform 15

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:187 → 264
      Ig_3; Immunoglobulin domain
      cd00096
      Location:188 → 194
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:21 → 97
      Ig; Immunoglobulin domain

    15. NM_001386966.1 → NP_001373895.1  neurotrimin isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variant 36, encodes isoform 16.
      Source sequence(s)
      AP000844, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    16. NM_001386967.1 → NP_001373896.1  neurotrimin isoform 17

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:217 → 294
      Ig_3; Immunoglobulin domain
      cd00096
      Location:218 → 224
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:51 → 127
      Ig; Immunoglobulin domain

    17. NM_001386968.1 → NP_001373897.1  neurotrimin isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variant 5, encodes isoform 5.
      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    18. NM_001386969.1 → NP_001373898.1  neurotrimin isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (36), as well as variant 23, encodes isoform 16.
      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155
      UniProtKB/TrEMBL
      B7Z1H3
      Conserved Domains (3) summary
      pfam13927
      Location:181 → 258
      Ig_3; Immunoglobulin domain
      cd00096
      Location:182 → 188
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:3 → 91
      Ig; Immunoglobulin domain

    19. NM_016522.3 → NP_057606.1  neurotrimin isoform 1 precursor

      See identical proteins and their annotated locations for NP_057606.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region, compared to variant 3. This variant encodes isoform 1, which is shorter than isoform 3.
      Source sequence(s)
      AP000844, AP004248, AP005155
      Consensus CDS
      CCDS8491.1
      UniProtKB/Swiss-Prot
      A0MTT2, Q6UXJ3, Q86VJ9, Q9P121
      UniProtKB/TrEMBL
      B7Z1H3
      Related
      ENSP00000363918.1, ENST00000374786.5
      Conserved Domains (3) summary
      pfam13927
      Location:222 → 299
      Ig_3; Immunoglobulin domain
      cd00096
      Location:223 → 229
      Ig; putative Ig strand A [structural motif]
      cl11960
      Location:44 → 132
      Ig; Immunoglobulin domain

    RNA

    1. NR_147848.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    2. NR_147849.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248

    3. NR_147850.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    4. NR_147851.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    5. NR_147852.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248

    6. NR_147853.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    7. NR_147854.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248

    8. NR_170346.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP003166, AP004248, AP005155

    9. NR_170347.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    10. NR_170348.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP003166, AP004248, AP005155

    11. NR_170349.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248

    12. NR_170350.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP003166, AP004248, AP005155

    13. NR_170351.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP003166, AP004248, AP005155

    14. NR_170352.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP003166, AP004248, AP005155

    15. NR_170354.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    16. NR_170355.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    17. NR_170357.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    18. NR_170358.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003039, AP004248, AP005155

    19. NR_170359.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    20. NR_170360.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    21. NR_170361.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP004248, AP005155

    22. NR_170362.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP004248
      Related
      ENST00000474900.5

    23. NR_170363.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP004248
      Related
      ENST00000539799.5

    24. NR_170364.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP004248

    25. NR_170365.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP004248

    26. NR_170366.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000844, AP003166, AP004248, AP005155

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      131370615..132336822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      131406501..132375341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P121.1 GenPept UniProtKB/Swiss-Prot:Q9P121

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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