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    mafaa MAF bZIP transcription factor Aa [ Danio rerio (zebrafish) ]

    Gene ID: 100000492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mafaaprovided by ZNC
    Official Full Name
    MAF bZIP transcription factor Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010605-3
    See related
    Ensembl:ENSDARG00000044155 AllianceGenome:ZFIN:ZDB-GENE-010605-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mafa; mafl; SMaf1
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in myotome; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mafaa in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (32699363..32703518, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (32714673..32718828, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 4 Neighboring gene uncharacterized LOC137495884 Neighboring gene zinc finger CCCH-type containing 3 Neighboring gene cylindromatosis (turban tumor syndrome), like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization, and expression analysis of zebrafish large Mafs. Kajihara M, et al. J Biochem, 2001 Jan. PMID 11134968
    2. Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Kölsch Y, et al. Neuron, 2021 Feb 17. PMID 33357413, Free PMC Article
    3. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Kim JW, et al. Dev Cell, 2016 Jun 20. PMID 27326930, Free PMC Article
    4. Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. Coolen M, et al. Dev Genes Evol, 2005 Jul. PMID 15759153
    5. Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Kajihara M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680841

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor MafAa
    Names
    Transcription factor MafA
    somite Maf1
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L
    v-maf musculoaponeurotic fibrosarcoma oncogene homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082940.2 → NP_001076409.1  transcription factor MafAa

      See identical proteins and their annotated locations for NP_001076409.1

      Status: VALIDATED

      Source sequence(s)
      CU694370, EH441535, EH467419
      UniProtKB/Swiss-Prot
      A3KMR8, Q98UK3
      UniProtKB/TrEMBL
      B3DGB3
      Related
      ENSDARP00000064832.4, ENSDART00000064833.5
      Conserved Domains (2) summary
      cd14718
      Location:218 → 287
      bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
      pfam08383
      Location:106 → 139
      Maf_N; Maf N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      32699363..32703518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KMR8.1 GenPept UniProtKB/Swiss-Prot:A3KMR8

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