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    GSTO1 glutathione S-transferase omega 1 [ Homo sapiens (human) ]

    Gene ID: 9446, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GSTO1provided by HGNC
    Official Full Name
    glutathione S-transferase omega 1provided by HGNC
    Primary source
    HGNC:HGNC:13312
    See related
    Ensembl:ENSG00000148834 MIM:605482; AllianceGenome:HGNC:13312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
    Summary
    The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GSTO1 in Genome Data Viewer
    Location:
    10q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (104254173..104267455)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (105142310..105155591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106013931..106027213)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1977 Neighboring gene microRNA 609 Neighboring gene Sharpr-MPRA regulatory region 2425 Neighboring gene uncharacterized LOC124902497 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:106013818-106014332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3979 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3983 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:106058991-106060190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:106060509-106061008

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water. Escobar-García DM, et al. Arch Toxicol, 2012 Jun. PMID 22293942
    2. Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs. Schmuck E, et al. Int J Biochem Cell Biol, 2008. PMID 18571971
    3. Nuclear translocation of glutathione transferase omega is a progression marker in Barrett's esophagus. Piaggi S, et al. Oncol Rep, 2009 Feb. PMID 19148497
    4. Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity. Piaggi S, et al. Carcinogenesis, 2010 May. PMID 20106899
    5. GSTO1 regards as a meritorious regulator in cutaneous malignant melanoma cells. Wang LK, et al. Mol Cell Probes, 2019 Dec. PMID 31525447

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer.
      Title: Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer.
    2. GSTO1 confers drug resistance in HCT116 colon cancer cells through an interaction with TNFalphaIP3/A20.
      Title: GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.
    3. The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
      Title: The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
    4. Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
      Title: Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.
    5. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
      Title: Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
    6. Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
      Title: Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
    7. Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
      Title: Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.
    8. Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
      Title: Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
    9. Glutathione Stransferase omega 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of nonsmall cell lung cancer cells, via the JAK/STAT3 signaling pathway.
      Title: Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.
    10. Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
      Title: Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686H13163

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-ascorbic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase omega-1
    Names
    MMA(V) reductase
    S-(Phenacyl)glutathione reductase
    epididymis secretory protein Li 21
    glutathione S-transferase omega 1-1
    glutathione-S-transferase like
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_001177931.1
    NP_001177932.1
    NP_004823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023362.1 RefSeqGene

      Range
      5699..18262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001191002.2 → NP_001177931.1  glutathione S-transferase omega-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CA431506, CN283947, DT220068
      Consensus CDS
      CCDS53572.1
      UniProtKB/TrEMBL
      Q5TA01
      Related
      ENSP00000358724.4, ENST00000369710.8
      Conserved Domains (3) summary
      cd03184
      Location:84 → 196
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      COG0625
      Location:26 → 177
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03055
      Location:5 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_001191003.2 → NP_001177932.1  glutathione S-transferase omega-1 isoform 3

      See identical proteins and their annotated locations for NP_001177932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL139341, CA431506, CF130513, DB501888
      Consensus CDS
      CCDS53573.1
      UniProtKB/TrEMBL
      Q5TA02
      Related
      ENSP00000441488.1, ENST00000539281.5
      Conserved Domains (3) summary
      PRK10542
      Location:12 → 192
      PRK10542; glutathionine S-transferase; Provisional
      cd03184
      Location:80 → 201
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cl00388
      Location:1 → 66
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_004832.3 → NP_004823.1  glutathione S-transferase omega-1 isoform 1

      See identical proteins and their annotated locations for NP_004823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BX537431
      Consensus CDS
      CCDS7555.1
      UniProtKB/Swiss-Prot
      D3DRA3, F5H7H0, P78417, Q5TA03, Q7Z3T2
      UniProtKB/TrEMBL
      B2R983, V9HWG9
      Related
      ENSP00000358727.5, ENST00000369713.10
      Conserved Domains (2) summary
      cd03184
      Location:108 → 229
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:5 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      104254173..104267455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      105142310..105155591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78417.2 GenPept UniProtKB/Swiss-Prot:P78417

    Gene LinkOut

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