BDNF brain derived neurotrophic factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: BDNFprovided by HGNC
Official Full Name: brain derived neurotrophic factorprovided by HGNC
Primary source: HGNC:HGNC:1033
See related: Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANON2; BULN2
Summary: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Expression: Biased expression in brain (RPKM 3.0), lung (RPKM 1.2) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p14.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (27654893..27722030, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (27795301..27862460, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (27676440..27743577, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors.
Title: Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors.
Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early-onset Parkinson's disease.
Title: Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early‑onset Parkinson's disease.
APOExBDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
Title: APOE×BDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.
Title: Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.
NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.
Title: NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.
Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
Title: Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
Brain-derived neurotrophic factor G196A (rs6265) gene polymorphism increases Turner syndrome susceptibility.
Title: Brain-derived neurotrophic factor G196A (rs6265) gene polymorphism increases Turner syndrome susceptibility.
The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review.
Title: The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review.
BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.
Title: BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.
Association of BDNF polymorphism with gestational diabetes mellitus risk: a novel insight into genetic predisposition.
Title: Association of BDNF polymorphism with gestational diabetes mellitus risk: a novel insight into genetic predisposition.

Submit: New GeneRIF Correction See all GeneRIFs (2319)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study identifies KCNMA1 contributing to human obesity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analyses identify multiple loci associated with smoking behavior. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production	PubMed
Tat	tat	The gene expression of brain-derived neurotrophic factor is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells	PubMed
	tat	Human BDNF is protective to neuroblastoma cells exposed to HIV-1 Tat	PubMed
	tat	HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BDNF-1 (e-PCR)
- UniSTS:253960

BDNF (e-PCR)
- UniSTS:266531

GDB:197571 (e-PCR)
- UniSTS:155950

BDNF (e-PCR)
- UniSTS:12882

D11S4115 (e-PCR), detects polymorphism
- UniSTS:73352

BDNF_2411 (e-PCR)
- UniSTS:280459

D11S1270 (e-PCR)
- UniSTS:148364

D11S2825 (e-PCR)
- UniSTS:152013

D11S4429 (e-PCR)
- UniSTS:43225

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	TAS Traceable Author Statement more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of brain-derived neurotrophic factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization to cell surface	TAS Traceable Author Statement more info	PubMed
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurotrophic factor BDNF precursor form

Names: abrineurin; neurotrophin; proBDNF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011794.2 RefSeqGene

Range

26575..72137

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001143805.1 → NP_001137277.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137277.1

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674517

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000432035.1, ENST00000525950.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143806.1 → NP_001137278.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137278.1

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674518

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000379302.3, ENST00000395978.7

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143807.2 → NP_001137279.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137279.1

Status: REVIEWED

Description

Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000435805.1, ENST00000532997.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143808.2 → NP_001137280.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137280.1

Status: REVIEWED

Description

Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000379307.3, ENST00000395983.7

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143809.2 → NP_001137281.1 neurotrophic factor BDNF precursor form isoform d precursor

See identical proteins and their annotated locations for NP_001137281.1

Status: REVIEWED

Description

Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.

Source sequence(s)

AC104563, KF459669

UniProtKB/Swiss-Prot

P23560

Conserved Domains (1) summary

smart00140
Location:162 → 269

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143810.2 → NP_001137282.1 neurotrophic factor BDNF precursor form isoform e

See identical proteins and their annotated locations for NP_001137282.1

Status: REVIEWED

Description

Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.

Source sequence(s)

AC104563, KF455346, KF459669

Consensus CDS

CCDS44558.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000414303.1, ENST00000438929.5

Conserved Domains (1) summary

smart00140
Location:215 → 322

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143811.2 → NP_001137283.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137283.1

Status: REVIEWED

Description

Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF455346, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143812.2 → NP_001137284.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137284.1

Status: REVIEWED

Description

Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000435564.1, ENST00000530861.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143813.2 → NP_001137285.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137285.1

Status: REVIEWED

Description

Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000432376.1, ENST00000533246.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143814.2 → NP_001137286.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137286.1

Status: REVIEWED

Description

Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000400502.1, ENST00000418212.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001143816.2 → NP_001137288.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001137288.1

Status: REVIEWED

Description

Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000389345.2, ENST00000439476.6

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001709.5 → NP_001700.2 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_001700.2

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000349084.4, ENST00000356660.9

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_170731.5 → NP_733927.1 neurotrophic factor BDNF precursor form isoform b precursor

See identical proteins and their annotated locations for NP_733927.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.

Source sequence(s)

AC103796, AC104563, KF459669

Consensus CDS

CCDS7865.1

UniProtKB/TrEMBL

A0A0S2Z3E7

Related

ENSP00000320002.6, ENST00000314915.6

Conserved Domains (1) summary

smart00140
Location:141 → 248

NGF; Nerve growth factor (NGF or beta-NGF)
NM_170732.4 → NP_733928.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_733928.1

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

EF674519

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000379305.3, ENST00000395981.7

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_170733.4 → NP_733929.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_733929.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENST00000584049.5

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)
NM_170734.4 → NP_733930.1 neurotrophic factor BDNF precursor form isoform c precursor

See identical proteins and their annotated locations for NP_733930.1

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS41628.1

UniProtKB/Swiss-Prot

P23560

Related

ENSP00000379309.2, ENST00000395986.6

Conserved Domains (1) summary

smart00140
Location:148 → 255

NGF; Nerve growth factor (NGF or beta-NGF)
NM_170735.6 → NP_733931.1 neurotrophic factor BDNF precursor form isoform a preproprotein

See identical proteins and their annotated locations for NP_733931.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).

Source sequence(s)

AC104563, KF459669

Consensus CDS

CCDS7866.1

UniProtKB/Swiss-Prot

A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24

UniProtKB/TrEMBL

A0A0E3SU01, A0A0S2Z3E7

Related

ENSP00000437138.1, ENST00000525528.1

Conserved Domains (1) summary

smart00140
Location:133 → 240

NGF; Nerve growth factor (NGF or beta-NGF)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

27654893..27722030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

27795301..27862460 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001143815.1: Suppressed sequence

Description

NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.