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    ZNF83 zinc finger protein 83 [ Homo sapiens (human) ]

    Gene ID: 55769, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF83provided by HGNC
    Official Full Name
    zinc finger protein 83provided by HGNC
    Primary source
    HGNC:HGNC:13158
    See related
    Ensembl:ENSG00000167766 MIM:194558; AllianceGenome:HGNC:13158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPF1; ZNF816B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 32.1), prostate (RPKM 31.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF83 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52612377..52690496, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55696827..55774933, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53115630..53193749, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53072140-53072749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53073969-53074577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15051 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53091538-53091757 Neighboring gene zinc finger protein 701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53104606-53105112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15054 Neighboring gene zinc finger protein 137, pseudogene Neighboring gene zinc finger protein 677-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53140536-53141054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53141055-53141572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10996 Neighboring gene Sharpr-MPRA regulatory region 1800 Neighboring gene Zinc finger protein LOC122539214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53167404-53167904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53171845-53172346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:53172853-53174052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53177263-53177762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53179336-53179900 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53179901-53180465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53192883-53193418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53196613-53197148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53199383-53200194 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201006-53201816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201817-53202627 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53219681-53220253 Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8. Lyu ZJ, et al. Mol Ther, 2021 Jan 6. PMID 33002420, Free PMC Article
    2. Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4. Marine JC, et al. Genomics, 1994 May 1. PMID 8088807
    3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
    4. Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency. Bajrami I, et al. Commun Biol, 2021 Nov 8. PMID 34750509, Free PMC Article
    5. Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. Huang YP, et al. World J Gastroenterol, 2005 Sep 28. PMID 16237761, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11015, FLJ14876, FLJ30097, FLJ90585, MGC33853

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 83
    Names
    zinc finger protein 816B
    zinc finger protein HPF1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052996.1 RefSeqGene

      Range
      5001..83218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001105549.2 → NP_001099019.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001099019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the supported protein. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BC032867, BG260506, BG741860, BX641726, DA107683, DA183557, DB107467
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001105550.2 → NP_001099020.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001099020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BG260506, BG741860, DA107683, DA151844, DA183557, DB107467
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Related
      ENSP00000516274.2, ENST00000706199.2
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001105551.2 → NP_001099021.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001099021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BG260506, BG741860, DA107683, DB107467, DB252431
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Related
      ENSP00000473096.2, ENST00000597161.7
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001105552.2 → NP_001099022.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001099022.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BG260506, BG741860, DA107683, DA449506, DB107467
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Related
      ENSP00000445993.3, ENST00000536937.7
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001277945.2 → NP_001264874.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264874.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AK075066, BC013321, BG399319, DA258790, DA380756
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001277946.2 → NP_001264875.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264875.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AK289399, BC013321, BG399319, DA258790, DA380756, DA434207, DB254966
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001277947.2 → NP_001264876.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA701045, DT216882
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001277948.2 → NP_001264877.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264877.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AK075066, BC013321, BG399319, DA258790, DA380756, DB134270, DB272526
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001277949.2 → NP_001264878.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA434207
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001277951.2 → NP_001264880.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, BC013321, DA258790, DA380756, DA731895
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Related
      ENSP00000440713.1, ENST00000545872.1
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001277952.2 → NP_001264881.1  zinc finger protein 83

      See identical proteins and their annotated locations for NP_001264881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BC013321, DA258790, DA341245, DA380756
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001348015.2 → NP_001334944.1  zinc finger protein 83

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AK075066, BC013321, BG399319, BX641726, DA258790, DA380756
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001348016.2 → NP_001334945.1  zinc finger protein 83

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, DA258790, DA380756, DA731895
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001348017.2 → NP_001334946.1  zinc finger protein 83

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. NM_001348018.2 → NP_001334947.1  zinc finger protein 83

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. NM_001348019.2 → NP_001334948.1  zinc finger protein 83

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA701045, DT216882
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. NM_018300.4 → NP_060770.3  zinc finger protein 83

      See identical proteins and their annotated locations for NP_060770.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
      Source sequence(s)
      AA883993, BG260506, BG741860, DA107683, DA183557, DB107467, DR761375
      Consensus CDS
      CCDS12854.1
      UniProtKB/Swiss-Prot
      A8MT75, P51522, Q3ZCX0, Q6PI08
      Related
      ENSP00000301096.3, ENST00000301096.8
      Conserved Domains (2) summary
      COG5048
      Location:117 → 507
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52612377..52690496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55696827..55774933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105553.1: Suppressed sequence

      Description
      NM_001105553.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

    2. NM_001105554.1: Suppressed sequence

      Description
      NM_001105554.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

    3. NM_001242531.1: Suppressed sequence

      Description
      NM_001242531.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

    4. NM_001242538.1: Suppressed sequence

      Description
      NM_001242538.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

    5. NR_003936.1: Suppressed sequence

      Description
      NR_003936.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51522.3 GenPept UniProtKB/Swiss-Prot:P51522

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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