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    ABCG40 pleiotropic drug resistance 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838122, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCG40
    Official Full Name
    pleiotropic drug resistance 12
    Primary source
    TAIR:AT1G15520
    Locus tag
    AT1G15520
    See related
    Araport:AT1G15520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA ATP-BINDING CASSETTE FAMILY G 40; Arabidopsis thaliana ATP-binding cassette G40; ATABCG40; ATP-BINDING CASSETTE FAMILY G40; ATP-binding cassette G40; ATPDR12; PDR12; pleiotropic drug resistance 12; PLEIOTROPIC DRUG RESISTANCE 12; T16N11.3; T16N11_3
    Summary
    ABC transporter family involved in ABA transport and resistance to lead. Localizes to plasma membrane. Upregulated by lead. Expressed in leaves, flowers, stomata and roots.
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    Genomic context

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    See ABCG40 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Sequence:
    Chromosome: 1; NC_003070.9 (5331858..5338326, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TLC ATP/ADP transporter Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene miscRNA Neighboring gene Concanavalin A-like lectin protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid. Kang J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20133880, Free PMC Article
    2. AtPDR12 contributes to lead resistance in Arabidopsis. Lee M, et al. Plant Physiol, 2005 Jun. PMID 15923333, Free PMC Article
    3. The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea. He Y, et al. Plant Cell, 2019 Sep. PMID 31239392, Free PMC Article
    4. WRKY1 regulates stomatal movement in drought-stressed Arabidopsis thaliana. Qiao Z, et al. Plant Mol Biol, 2016 May. PMID 26820136
    5. Sorghum extracellular leucine-rich repeat protein SbLRR2 mediates lead tolerance in transgenic Arabidopsis. Zhu FY, et al. Plant Cell Physiol, 2013 Sep. PMID 23877877

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The pleiotropic drug resistance (PDR) transporter PENETRATION3 (PEN3)/PDR8 in Arabidopsis (Arabidopsis thaliana) has been implicated in resistance to a variety of fungal pathogens. The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
      Title: The Arabidopsis Pleiotropic Drug Resistance Transporters PEN3 and PDR12 Mediate Camalexin Secretion for Resistance to Botrytis cinerea.
    2. ABCG40 imports abscisic acid into the embryo, regulating seed germination.
      Title: Abscisic acid transporters cooperate to control seed germination.
    3. Data suggest that Sorghum SbLRR2(Sb05g018800)appears to mediate Pb(II) tolerance through the elevation of AtPDR12 expression in transgenic Arabidopsis, thus activating a glutathione-independent mechanism for detoxification.
      Title: Sorghum extracellular leucine-rich repeat protein SbLRR2 mediates lead tolerance in transgenic Arabidopsis.
    4. report the identification of the ATP-binding cassette (ABC) transporter Pleiotropic drug resistance transporter PDR12 (AtPDR12)/ABCG40 as a plasma membrane abscisic acid uptake transporter
      Title: PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid.
    5. The results suggest that EIN2 gene mediates Pb(II) resistance, at least in part, through two distinct mechanisms, a GSH-dependent mechanism and a GSH-independent AtPDR12-mediated mechanism.
      Title: The Arabidopsis Ethylene-Insensitive 2 gene is required for lead resistance.
    6. PDR12 is an ABC transporter that contributes to lead resistance in Arabidopsis. [AtPDR12]
      Title: AtPDR12 contributes to lead resistance in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001332173.1
    NM_101421.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in abscisic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intercellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lead ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within terpenoid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleiotropic drug resistance 12
    NP_173005.1
    • pleiotropic drug resistance 12 (PDR12); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), Plant PDR ABC transporter associated (InterPro:IPR013581), ABC-2 type transporter (InterPro:IPR013525); BEST Arabidopsis thaliana protein match is: pleiotropic drug resistance 11 (TAIR:AT1G66950.1); Has 377983 Blast hits to 279992 proteins in 3946 species: Archae - 7615; Bacteria - 304057; Metazoa - 8776; Fungi - 6428; Plants - 5794; Viruses - 2; Other Eukaryotes - 45311 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5331858..5338326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101421.3 → NP_173005.1  pleiotropic drug resistance 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173005.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M9E1
      UniProtKB/TrEMBL
      A0A5S9ULY7, A0A654EFA3
      Conserved Domains (1) summary
      PLN03140
      Location:10 → 1423
      PLN03140; ABC transporter G family member; Provisional

    2. NM_001332173.1 → NP_001323077.1  pleiotropic drug resistance 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WCE1, A0A1P8AW07
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M9E1.1

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