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Asp
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asp
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A pool of ASP-overlapping peptides enhance IFN-gamma responses of T cells in HIV-1 seropositive patients |
PubMed
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asp
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Antisense reading frame-derived cryptic epitopes from the env gene induce upregulation of IFNG immune-response on the surface of CD8+ T-cells |
PubMed
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Envelope surface glycoprotein gp120
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env
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Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta |
PubMed
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env
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Treatment of cells with HIV-1 gp120 induces the release of IFN gamma |
PubMed
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env
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HIV-1 Env gp120 peptides can stimulate cytoplasmic IFN-gamma response in CD8+ T cells in the presence of dendritic cells |
PubMed
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env
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HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes |
PubMed
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env
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HIV-1 gp120-treated myeloid dendritic cell (mDC) downregulates IL-2 and IFN-gamma production compared to LPS-treated mDC |
PubMed
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env
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Frequent IFN-gamma and TNF-alpha NK cell responses to HIV-1 gp120 are dominant during chronic HIV-1 infection |
PubMed
|
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env
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HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells inhibits IFN-gamma release from autologous T cells |
PubMed
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env
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IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells |
PubMed
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env
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NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 |
PubMed
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env
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Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves the p38 MAPK signaling pathway |
PubMed
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env
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Peptides of gp120 representing binding regions for CD4 and chemokine receptors, as well as CD4 antibody, inhibit gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) |
PubMed
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env
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HIV-1 gp120 in the presence of IFN-gamma induces cytotoxicity of human brain micro vascular endothelial cells (HBMECs) derived from children but not from adults |
PubMed
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env
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Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 |
PubMed
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env
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In the presence of HIV-1 gp120, stimulation through the CD28 pathway partially restores IL-2 and IFN-gamma production by T cell lines in response to anti-CD3 antibodies |
PubMed
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env
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HIV-1 gp120 inhibits natural killer (NK) cell natural cytotoxicity and this inhibition also affects the production of the proinflammatory cytokine interferon-gamma (IFN-gamma); the inhibitory activity of gp120 can be prevented by coincubation with VIP |
PubMed
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env
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Induction of the receptor activator of cytokine nuclear factor kappa B ligand (RANKL) is mediated by HIV-1 gp120; the gp120-mediated induction of RANKL is blocked by interferon-gamma |
PubMed
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env
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Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120 |
PubMed
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env
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Secretion of IL-2 and IFN-gamma stimulated with anti-CD3 antibodies is inhibited by HIV-1 gp120 in T cell lines |
PubMed
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env
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Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) |
PubMed
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env
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HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 |
PubMed
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env
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IFN-gamma and gp120-induced activation of Na+/H+ exchange appears to be mediated through activation of tyrosine kinase (TK), because TK inhibitors block the action of IFN-gamma and gp120 |
PubMed
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env
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Treatment of human colonic epithelial cells with recombinant gamma-interferon (rlFN gamma) induces a dose-dependent inhibition of Galactosyl ceramide (GalCer) expression on the cell surface; GalCer is a receptor for HIV-1 gp120 |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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HIV-1 Env induces release of IFN-gamma from CAR-transduced T cells |
PubMed
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env
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Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production |
PubMed
|
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Envelope transmembrane glycoprotein gp41
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env
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A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IFN-gamma in peptide-treated PBMCs |
PubMed
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env
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PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells |
PubMed
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env
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IFN-gamma production in mononuclear leukocytes from an HIV-1-seropositive man is induced by different concentrations of a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment |
PubMed
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|
Nef
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nef
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HIV-1 Nef-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells |
PubMed
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nef
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The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point |
PubMed
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nef
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Coincubation of HIV-1 Nef and IFN-gamma downregulates COX-2 expression compared to untreated, Nef- or IFN-gamma-treated Caco-2 cells |
PubMed
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nef
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HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production |
PubMed
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nef
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Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression |
PubMed
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nef
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HIV-1 Nef has super antigen properties in that it binds to MHC class II antigens and activates T cells, causing T cell proliferation and production of the T helper 1 cytokines IL-2 and IFN-gamma |
PubMed
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nef
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Upon T cell activation, HIV-1 Nef expression downregulates both IL-2 and IFN-gamma production in a dose-dependent manner |
PubMed
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nef
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PBMC proliferation induced by exogenous HIV-1 Nef is associated with upregulation of interferon-gamma (IFN-gamma) |
PubMed
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Pr55(Gag)
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gag
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Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells |
PubMed
|
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gag
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HIV-1-exposed monocyte-derived dendritic cells induce weak secretion of IFN-gamma and low amounts of intracellular Gag expression in the presence of SAMHD1 |
PubMed
|
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gag
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HIV-1 Gag peptides can stimulate cytoplasmic IFN-gamma response in CD8 T cells |
PubMed
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gag
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MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells |
PubMed
|
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gag
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The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point |
PubMed
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gag
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IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression |
PubMed
|
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gag
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Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline in patients |
PubMed
|
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gag
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HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IFN-gamma in a dose and time dependent manner |
PubMed
|
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gag
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HIV-1 Gag virus-like particle-induced human monocyte-derived dendritic cell maturation activates autologous NK cells, leading to their proliferation, and production of interferon-gamma |
PubMed
|
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gag
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HIV-1 Gag p24-specific CD4+ T cells producing IL-2 and IFN-gamma are increased post vaccination |
PubMed
|
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gag
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Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to Sheep Red Cell Antigen |
PubMed
|
|
gag
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The Capsid (p24) protein of HIV-1 Gag inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 |
PubMed
|
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gag
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The Matrix protein of HIV-1 Gag enhances the cytokine-induced production of interferon gamma |
PubMed
|
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gag
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The Matrix protein of HIV-1 Gag and interferon gamma are structurally similar and have been found to bind in vitro |
PubMed
|
|
Tat
|
tat
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HIV-1 Tat upregulates the production of cytokines, including TNF-alpha, IL-6, IL-10, IL-12, IFN-alpha1, and IFN-gamma, in human monocyte derived-dendritic cells and in primary human Muller glia |
PubMed
|
|
tat
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HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells |
PubMed
|
|
tat
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The contact between peptide-stimulated CD8+ T-lymphocytes and immobilized HIV-1 Tat inhibits the release of IFN-gamma |
PubMed
|
|
tat
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HIV-1 Tat upregulates IL-2 and IFN-gamma production in stimulated CD8+ T cells |
PubMed
|
|
tat
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JAK/STAT pathway plays a major role in Tat/IFN-gamma-mediated CXCL10 induction in macrophages |
PubMed
|
|
tat
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The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes |
PubMed
|
|
tat
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HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells |
PubMed
|
|
tat
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Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor |
PubMed
|
|
tat
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HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase |
PubMed
|
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tat
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HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation |
PubMed
|
|
tat
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Pretreatment of THP-1 cells with HIV-1 Tat/T-bet co-cultures with CD4+T cells, resulting in increased levels of IFN-gamma |
PubMed
|
|
tat
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HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity |
PubMed
|
|
tat
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HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha |
PubMed
|
|
tat
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HIV-1 Tat acts as a co-stimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-gamma secretion |
PubMed
|
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tat
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HIV-1 Tat interacts with IFN-gamma, which upregulates the Tat receptor VEGFR2/KDR, to produce cytotoxicity in human brain micro vascular endothelial cells |
PubMed
|
|
tat
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HIV-1 Tat upregulates IFN-gamma expression by uninfected mononuclear cells |
PubMed
|
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tat
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HIV-1 Tat inhibits IFN-gamma release by NK cells upon contact with dendritic cells |
PubMed
|
|
tat
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HIV-1 Tat delivered by CyaA from Bordetella pertussis induces a Th1-polarized immune response and HIV-Tat-specific gamma interferon-producing CD8(+) T cells are generated after vaccination with CyaA-E5-Tat in a CD4(+) T-cell-independent manner |
PubMed
|
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tat
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HIV-1 Tat synergizes with IFN-gamma to induce iNOS activity in purified rat microglial cultures |
PubMed
|
|
tat
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IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS |
PubMed
|
|
tat
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IFN-gamma inhibits the transactivation of the HIV-1 LTR promoter by HIV-1 Tat |
PubMed
|
|
tat
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HIV-1 Tat inhibits IFN-gamma induced iNOS activity in a murine macrophage cell line |
PubMed
|
|
tat
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IL-1beta, TNF-alpha, and IFN-gamma synergize with HIV-1 Tat to promote in nude mice the development of angioproliferative Kaposi's sarcoma-like lesions |
PubMed
|
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tat
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HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication |
PubMed
|
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Vif
|
vif
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HIV-1 Vif downregulates the expression of interferon-gamma (IFNG) in Vif-expression T cells |
PubMed
|
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Vpr
|
vpr
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Exogenous Vpr compromises subsequent pDC/NK interplay through inhibition of IFN-gamma production by NK cells |
PubMed
|
|
vpr
|
HIV-1 Vpr inhibits interferon gamma secretion in infected T cells |
PubMed
|
|
vpr
|
HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway |
PubMed
|
|
vpr
|
Expression of HIV-1 Vpr in U937 cells upregulates gamma interferon expression |
PubMed
|
|
capsid
|
gag
|
Peptides derived from HIV-1 p24 induces release of IFN-gamma in monocyte-derived DCs and macrophages |
PubMed
|
|
gag
|
PLA-p24- or p24-loaded human monocyte-derived dendritic cells enhance HIV-1-specific T-cell response by increased levels of IFN-gamma and IL-2 in comparison with PLA-loaded cells alone |
PubMed
|
|
gag
|
HIV-1 CA-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells |
PubMed
|
|
gag
|
IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression |
PubMed
|
|
gag
|
IFN-gamma and/or IL-2 responses characterized by secreting cells contribute more to the HIV-1 CA specific response in acute infection early disease (AIED) than in chronically infected individuals |
PubMed
|
|
gag
|
Pretreating dendritic cells with INF-gamma overcomes the HIV-1 CA-mediated decreased levels of presentation of ovalbumin to a SIINFEKL-specific CD8(+) T-cell hybridoma |
PubMed
|
|
gag
|
HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 |
PubMed
|
|
gag
|
Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to Sheep Red Cell Antigen |
PubMed
|
|
matrix
|
gag
|
HIV-1 Matrix enhances the cytokine-induced production of interferon gamma |
PubMed
|
|
gag
|
HIV-1 Matrix and interferon gamma are structurally similar and have been found to bind in vitro |
PubMed
|
|
reverse transcriptase
|
gag-pol
|
Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT |
PubMed
|