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    unc-41 Putative stoned B-like protein [ Caenorhabditis elegans ]

    Gene ID: 179387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-41
    Official Full Name
    Putative stoned B-like protein
    Primary source
    WormBase:WBGene00006777
    Locus tag
    CELE_C27H6.1
    See related
    AllianceGenome:WB:WBGene00006777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Is expressed in nervous system. Orthologous to several human genes including STON2 (stonin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-41 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (9966380..9976238, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MADF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RuvB-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the unc-41 gene cause elevation of acetylcholine levels. Harada S, et al. J Neurochem, 1994 Aug. PMID 8035172
    2. Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells. Tanaka H, et al. Genes Cells, 2020 Jun. PMID 32167217
    3. UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. Mullen GP, et al. PLoS One, 2012. PMID 22808098, Free PMC Article
    4. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. Jung N, et al. J Cell Biol, 2007 Dec 31. PMID 18166656, Free PMC Article
    5. Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. Gu M, et al. J Cell Biol, 2008 Dec 1. PMID 19047463, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
      Title: Involvement of the synaptotagmin/stonin2 system in vesicular transport regulated by semaphorins in Caenorhabditis elegans epidermal cells.
    2. UNC-41 acts in the same endocytic pathway as micro2 adaptin.
      Title: UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative stoned B-like protein
    NP_001256157.1
    • Confirmed by transcript evidence
    NP_001256158.1
    • Partially confirmed by transcript evidence
    NP_001256159.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9966380..9976238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269228.3 → NP_001256157.1  Putative stoned B-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256157.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1B6U3, E1B6U4, E1B6U5, P90761
      Conserved Domains (2) summary
      cl10970
      Location:1279 → 1606
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
      cl17171
      Location:1145 → 1193
      PH-like; Pleckstrin homology-like domain

    2. NM_001269229.3 → NP_001256158.1  Putative stoned B-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256158.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90761
      Conserved Domains (2) summary
      cl10970
      Location:997 → 1324
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
      cl17171
      Location:863 → 911
      PH-like; Pleckstrin homology-like domain

    3. NM_001269230.3 → NP_001256159.1  Putative stoned B-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90761
      Conserved Domains (2) summary
      cl10970
      Location:906 → 1233
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
      cl17171
      Location:772 → 820
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90761.2

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