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    magi-1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178107, updated on 9-Dec-2024

    Summary

    Official Symbol
    magi-1
    Official Full Name
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein
    Primary source
    WormBase:WBGene00010444
    Locus tag
    CELE_K01A6.2
    See related
    AllianceGenome:WB:WBGene00010444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables beta-catenin binding activity and glutamate receptor binding activity. Involved in habituation; long-term memory; and regulation of protein localization. Located in adherens junction and synapse. Is expressed in several structures, including anus; egg-laying apparatus; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to several human genes including MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See magi-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    17
    Sequence:
    Chromosome: IV; NC_003282.8 (11715039..11729281)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-His Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Glycine Rich Secreted Protein Neighboring gene Collagen-like protein

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2;PDZ domain-containing protein
    NP_001255577.1
    • Confirmed by transcript evidence
    NP_001255579.1
    • Partially confirmed by transcript evidence
    NP_001255581.1
    • Partially confirmed by transcript evidence
    NP_001370254.1
    • Partially confirmed by transcript evidence
    NP_001379500.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11715039..11729281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268648.3NP_001255577.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255577.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P633
      Conserved Domains (5) summary
      smart00456
      Location:294323
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:421510
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:263293
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9681049
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17190
      Location:180244
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. NM_001383205.1NP_001370254.1  PDZ domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P635
      Conserved Domains (5) summary
      smart00456
      Location:294323
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:421510
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:263293
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:717800
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17190
      Location:180244
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. NM_001268650.4NP_001255579.1  Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P634
    4. NM_001392402.1NP_001379500.1  Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRJ8
      Conserved Domains (4) summary
      smart00456
      Location:4271
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:169258
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:1141
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:716797
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    5. NM_001268652.3NP_001255581.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT29
      Conserved Domains (2) summary
      smart00228
      Location:196285
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:743824
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...