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    gbb-2 Gamma-aminobutyric acid type B receptor subunit 2 [ Caenorhabditis elegans ]

    Gene ID: 191240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gbb-2
    Official Full Name
    Gamma-aminobutyric acid type B receptor subunit 2
    Primary source
    WormBase:WBGene00022675
    Locus tag
    CELE_ZK180.1
    See related
    AllianceGenome:WB:WBGene00022675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gbb-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    19
    Sequence:
    Chromosome: IV; NC_003282.8 (4488929..4506748, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PhoLip_ATPase_C domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein sleepless Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons. Schultheis C, et al. J Neurophysiol, 2011 Aug. PMID 21613582, Free PMC Article
    2. GABA Receptor mutant gbb-1 accelerates morphological aging of GABA neurons in Caenorhabditis elegans. Dhillon I, et al. MicroPubl Biol, 2018 Sep 6. PMID 32550395, Free PMC Article
    3. LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction. Sorkaç A, et al. G3 (Bethesda), 2018 Jul 31. PMID 29950427, Free PMC Article
    4. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. Dittman JS, et al. J Neurosci, 2008 Jul 9. PMID 18614679, Free PMC Article
    5. NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans. Yemini E, et al. Cell, 2021 Jan 7. PMID 33378642, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled GABA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled GABA receptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-aminobutyric acid type B receptor subunit 2
    NP_500579.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4488929..4506748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068178.5 → NP_500579.3  Gamma-aminobutyric acid type B receptor subunit 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500579.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7WN65, G5ECB2
      Conserved Domains (2) summary
      cd06366
      Location:50 → 395
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd15294
      Location:439 → 705
      7tmC_GABA-B-R2; gamma-aminobutyric acid type B receptor subunit 2, member of the class C family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECB2.1

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