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    kcnl-4 Calmodulin-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcnl-4
    Official Full Name
    Calmodulin-binding domain-containing protein
    Primary source
    WormBase:WBGene00008265
    Locus tag
    CELE_C53A5.5
    See related
    AllianceGenome:WB:WBGene00008265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kcnl-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (14531113..14543005)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Histone deacetylase 1 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene Serpentine receptor class gamma-47

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calmodulin-binding domain-containing protein
    NP_001256594.1
    • Confirmed by transcript evidence
    NP_001256595.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14531113..14543005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269665.3 → NP_001256594.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17697
      Conserved Domains (3) summary
      pfam03530
      Location:69 → 180
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:261 → 349
      Ion_trans_2; Ion channel
      cl03763
      Location:363 → 435
      CaMBD; Calmodulin binding domain

    2. NM_001269666.3 → NP_001256595.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256595.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCU0
      Conserved Domains (3) summary
      pfam03530
      Location:14 → 125
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:206 → 294
      Ion_trans_2; Ion channel
      cl03763
      Location:308 → 380
      CaMBD; Calmodulin binding domain
    Nucleotide Protein
    Heading Accession and Version

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