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    daam-1 FH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daam-1
    Official Full Name
    FH2 domain-containing protein
    Primary source
    WormBase:WBGene00018976
    Locus tag
    CELE_F56E10.2
    See related
    AllianceGenome:WB:WBGene00018976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to several human genes including DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daam-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (64530..83832, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The canonical eIF4E isoform of C. elegans regulates growth, embryogenesis, and germline sex-determination. Mangio RS, et al. Biol Open, 2015 May 15. PMID 25979704, Free PMC Article
    2. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Mi-Mi L, et al. J Cell Biol, 2012 Jul 9. PMID 22753896, Free PMC Article
    3. FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner. Sundaramurthy S, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 33103378, Free PMC Article
    4. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. King RS, et al. Dev Biol, 2009 Apr 15. PMID 19298786, Free PMC Article
    5. Wnt signaling establishes the microtubule polarity in neurons through regulation of Kinesin-13. Puri D, et al. J Cell Biol, 2021 Sep 6. PMID 34137792, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FH2 domain-containing protein
    NP_001300119.1
    • Partially confirmed by transcript evidence
    NP_001300120.1
    • Confirmed by transcript evidence
    NP_503132.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      64530..83832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070731.6 → NP_503132.3  FH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503132.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6VPA1
      Conserved Domains (3) summary
      smart00498
      Location:524 → 973
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:216 → 408
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:39 → 212
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001313190.3 → NP_001300119.1  FH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXY1
      Conserved Domains (2) summary
      smart00498
      Location:355 → 804
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:47 → 239
      Drf_FH3; Diaphanous FH3 Domain

    3. NM_001313191.3 → NP_001300120.1  FH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASL6
      Conserved Domains (1) summary
      smart00498
      Location:1 → 361
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version

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