ndx-9 NAD(+) diphosphatase;NAD-capped RNA hydrolase ndx-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ndx-9
Official Full Name: NAD(+) diphosphatase;NAD-capped RNA hydrolase ndx-9
Primary source: WormBase:WBGene00003586
Locus tag: CELE_F13H10.2
See related: AllianceGenome:WB:WBGene00003586
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in peroxisome. Orthologous to several human genes including NUDT13 (nudix hydrolase 13). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ndx-9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11010030..11012020, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F13H10.2 (e-PCR)
- UniSTS:314021

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NAD+ diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables NADH pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH pyrophosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA NAD-cap (NMN-forming) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADP catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NAD(+) diphosphatase;NAD-capped RNA hydrolase ndx-9

NP_001129853.1

Confirmed by transcript evidence

NP_502051.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11010030..11012020 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069650.7 → NP_502051.2 NAD-capped RNA hydrolase ndx-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502051.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19427, Q9GPZ5

Conserved Domains (1) summary

cd03429
Location:212 → 365

NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
NM_001136381.4 → NP_001129853.1 NAD(+) diphosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129853.1

Status: REVIEWED

UniProtKB/TrEMBL

B3GWC0

Conserved Domains (1) summary

cd03429
Location:186 → 339

NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...