gon-1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gon-1
Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein
Primary source: WormBase:WBGene00001650
Locus tag: CELE_F25H8.3
See related: AllianceGenome:WB:WBGene00001650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables metallopeptidase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; muscle organ morphogenesis; and negative regulation of presynapse assembly. Predicted to be located in several cellular components, including Golgi apparatus; basement membrane; and endoplasmic reticulum. Predicted to be active in extracellular matrix. Is expressed in several structures, including excretory cell; head mesodermal cell; muscle cell; neurons; and reproductive system. Used to study obesity and type 2 diabetes mellitus. Orthologous to several human genes including ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gon-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 31

Sequence:: Chromosome: IV; NC_003282.8 (9934206..9953433, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
Title: Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
propose that GON-1 regulates a developmental switch out of an initial "pro-growth" phase during which muscle arms grow out and form synapses with motor neuron axons.
Title: Regulation of synaptic extracellular matrix composition is critical for proper synapse morphology.
ADAMTS9 and GON-1 in the ER that promotes protein transport from the ER to the Golgi. This function is GON-domain dependent but protease activity independent.
Title: Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi.
GON-1 has human homologues that are in the same protease subfamily
Title: Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

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General gene information

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Markers

F25H8.3 (e-PCR)
- UniSTS:309946

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs gon-1;Peptidase M12B domain-containing protein

NP_001255448.1

Confirmed by transcript evidence

NP_001359558.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9934206..9953433 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001372913.1 → NP_001359558.1 A disintegrin and metalloproteinase with thrombospondin motifs gon-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19791, Q27524

Conserved Domains (6) summary

smart00209
Location:591 → 643

TSP1; Thrombospondin type 1 repeats

cd04273
Location:280 → 490

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:75 → 228

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:754 → 870

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1927 → 2122

GON; GON domain

pfam17771
Location:508 → 577

ADAM_CR_2; ADAM cysteine-rich domain
NM_001268519.3 → NP_001255448.1 Peptidase M12B domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255448.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L2A7

Conserved Domains (6) summary

smart00209
Location:591 → 658

TSP1; Thrombospondin type 1 repeats

cd04273
Location:280 → 490

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:280 → 493

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:93 → 228

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:769 → 885

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1942 → 2137

GON; GON domain