pcs-1 Glutathione gamma-glutamylcysteinyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pcs-1
Official Full Name: Glutathione gamma-glutamylcysteinyltransferase
Primary source: WormBase:WBGene00003960
Locus tag: CELE_F54D5.1
See related: AllianceGenome:WB:WBGene00003960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables glutathione gamma-glutamylcysteinyltransferase activity. Involved in detoxification of inorganic compound and phytochelatin biosynthetic process. Is expressed in several structures, including coelomocyte; non-striated muscle; pharyngeal-intestinal valve; pharynx; and rectal valve cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pcs-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (11574941..11577740, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that whilst the transcription of pcs-1 may not be mediated by an exposure zinc or cadmium, it is nevertheless an integral part of the cadmium detoxification pathway in C. elegans.
Title: Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans.
increase in arsenic tolerance in transformed tobacco plants
Title: Arsenic response of AtPCS1- and CePCS-expressing plants - effects of external As(V) concentration on As-accumulation pattern and NPT metabolism.
In contrast to wild type and CePCS transformants, AtPCS1 transformants were Cd-hypersensitive although there was no difference in cadmium accumulation between studied lines.
Title: Overexpression of phytochelatin synthase in tobacco: distinctive effects of AtPCS1 and CePCS genes on plant response to cadmium.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54D5.1 (e-PCR)
- UniSTS:307697

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione gamma-glutamylcysteinyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione gamma-glutamylcysteinyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione gamma-glutamylcysteinyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of cadmium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detoxification of cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detoxification of copper ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detoxification of copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of mercury ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detoxification of zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phytochelatin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phytochelatin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phytochelatin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phytochelatin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Glutathione gamma-glutamylcysteinyltransferase

NP_001122615.1

Confirmed by transcript evidence

NP_001122616.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11574941..11577740 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129143.5 → NP_001122615.1 Glutathione gamma-glutamylcysteinyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122615.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5JYS0, A5JYS1, G5ECE4

Conserved Domains (1) summary

pfam05023
Location:17 → 223

Phytochelatin; Phytochelatin synthase
NM_001129144.4 → NP_001122616.1 Glutathione gamma-glutamylcysteinyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122616.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JYS1

Conserved Domains (1) summary

pfam05023
Location:9 → 217

Phytochelatin; Phytochelatin synthase