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    zfh-2 Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein [ Caenorhabditis elegans ]

    Gene ID: 171670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfh-2
    Official Full Name
    Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein
    Primary source
    WormBase:WBGene00022518
    Locus tag
    CELE_ZC123.3
    See related
    AllianceGenome:WB:WBGene00022518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in body wall musculature; enteric muscle; nerve ring; neurons; and vulval muscle. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zfh-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (803368..834765)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A microcosm of the biomedical research experience for upper-level undergraduates. Hurd DD. CBE Life Sci Educ, 2008 Summer. PMID 18519612, Free PMC Article
    2. Genes in human obesity loci are causal obesity genes in C. elegans. Ke W, et al. PLoS Genet, 2021 Sep. PMID 34492009, Free PMC Article
    3. Functional transcriptomics of a migrating cell in Caenorhabditis elegans. Schwarz EM, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22991463, Free PMC Article
    4. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
    5. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein
    NP_001368413.1
    • Confirmed by transcript evidence
    NP_001368414.1
    • Confirmed by transcript evidence
    NP_001368415.1
    • Product from WormBase gene class zfh;
      Confirmed by transcript evidence
    NP_001368416.1
    • Product from WormBase gene class zfh;
      Confirmed by transcript evidence
    NP_001368417.1
    • Confirmed by transcript evidence
    NP_001370923.1
    • Product from WormBase gene class zfh;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      803368..834765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383286.2 → NP_001370923.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLN5
      Conserved Domains (5) summary
      smart00389
      Location:856 → 915
      HOX; Homeodomain
      COG5576
      Location:979 → 1091
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:502 → 525
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:1035 → 1087
      Homeobox; Homeobox domain

    2. NM_001380621.1 → NP_001368413.1  Zinc finger protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJA9
      Conserved Domains (5) summary
      smart00389
      Location:494 → 553
      HOX; Homeodomain
      COG5576
      Location:617 → 729
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:140 → 163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:673 → 725
      Homeobox; Homeobox domain

    3. NM_001380622.1 → NP_001368414.1  Zinc finger protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKG1
      Conserved Domains (5) summary
      smart00389
      Location:476 → 535
      HOX; Homeodomain
      COG5576
      Location:599 → 711
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:94 → 114
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:122 → 145
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:655 → 707
      Homeobox; Homeobox domain

    4. NM_001380626.1 → NP_001368415.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLT5
      Conserved Domains (6) summary
      smart00389
      Location:378 → 437
      HOX; Homeodomain
      smart00451
      Location:48 → 77
      ZnF_U1; U1-like zinc finger
      COG5576
      Location:501 → 613
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:24 → 47
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:557 → 609
      Homeobox; Homeobox domain

    5. NM_001380629.1 → NP_001368416.1  Zinc Finger and Homeobox [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLS4
      Conserved Domains (4) summary
      smart00389
      Location:264 → 323
      HOX; Homeodomain
      COG5576
      Location:387 → 499
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00020
      Location:819 → 841
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:443 → 495
      Homeobox; Homeobox domain

    6. NM_001380630.1 → NP_001368417.1  Zinc finger homeobox protein 4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLP1
      Conserved Domains (3) summary
      COG5576
      Location:92 → 204
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00020
      Location:524 → 546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:148 → 200
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

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