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    Sirt6 sirtuin 6 [ Mus musculus (house mouse) ]

    Gene ID: 50721, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sirt6provided by MGI
    Official Full Name
    sirtuin 6provided by MGI
    Primary source
    MGI:MGI:1354161
    See related
    Ensembl:ENSMUSG00000034748 AllianceGenome:MGI:1354161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sir2l6; mSIRT6; 2810449N18Rik
    Summary
    Enables several functions, including NAD+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; and TORC2 complex binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of nucleobase-containing compound metabolic process; and regulation of protein localization. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.8), ovary adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sirt6 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81457621..81463631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81621787..81627792, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transducin-like enhancer of split 2 Neighboring gene STARR-positive B cell enhancer ABC_E9796 Neighboring gene transducin-like enhancer of split 6 Neighboring gene STARR-positive B cell enhancer ABC_E2953 Neighboring gene STARR-positive B cell enhancer ABC_E464 Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_27345 Neighboring gene STARR-positive B cell enhancer ABC_E6888 Neighboring gene ankyrin repeat domain 24 Neighboring gene STARR-positive B cell enhancer ABC_E9797 Neighboring gene STARR-positive B cell enhancer ABC_E6889 Neighboring gene STARR-seq mESC enhancer starr_27348 Neighboring gene predicted gene 10778

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA damage sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA damage sensor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD+ binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+-protein ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+-protein-lysine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD-dependent protein demyristoylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD-dependent protein demyristoylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent protein depalmitoylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD-dependent protein depalmitoylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables TORC2 complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K14 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K18 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K18 deacetylase activity, NAD-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K4 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K56 deacetylase activity, NAD-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K9 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K9 deacetylase activity, NAD-dependent IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K9 deacetylase activity, NAD-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 deacetylase activity, NAD-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K9 deacetylase activity, NAD-dependent TAS
    Traceable Author Statement
    more info
     
    enables histone H4K16 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase activity, NAD-dependent ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase activity, NAD-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lncRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to endothelin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ketone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pericentric heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pericentric heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of blood vessel branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chondrocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-embryonic cardiac muscle cell growth involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein delipidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein delipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in subtelomeric heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in subtelomeric heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, subtelomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentric heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NAD-dependent protein deacylase sirtuin-6
    Names
    NAD-dependent deacetylase sirtuin-6
    NAD-dependent protein deacetylase sirtuin-6
    SIR2-like protein 6
    protein mono-ADP-ribosyltransferase sirtuin-6
    regulatory protein SIR2 homolog 6
    NP_001156902.1
    NP_001365873.1
    NP_001365874.1
    NP_853617.1
    XP_011241809.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163430.2NP_001156902.1  NAD-dependent protein deacylase sirtuin-6 isoform 2

      See identical proteins and their annotated locations for NP_001156902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the UTRs and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC153919
      Consensus CDS
      CCDS48645.1
      UniProtKB/TrEMBL
      Q3UKP1
      Related
      ENSMUSP00000113953.2, ENSMUST00000119324.8
      Conserved Domains (1) summary
      cd01410
      Location:5217
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    2. NM_001378944.1NP_001365873.1  NAD-dependent protein deacylase sirtuin-6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC153919
      UniProtKB/Swiss-Prot
      P59941
      Conserved Domains (1) summary
      cd01410
      Location:45257
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    3. NM_001378945.1NP_001365874.1  NAD-dependent protein deacylase sirtuin-6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC153919
      UniProtKB/TrEMBL
      Q3UKP1
      Conserved Domains (1) summary
      cd01410
      Location:5217
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
    4. NM_181586.4NP_853617.1  NAD-dependent protein deacylase sirtuin-6 isoform 1

      See identical proteins and their annotated locations for NP_853617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC153919
      Consensus CDS
      CCDS24066.1
      UniProtKB/Swiss-Prot
      P59941
      Related
      ENSMUSP00000048971.9, ENSMUST00000042923.9
      Conserved Domains (1) summary
      cd01410
      Location:45257
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

    RNA

    1. NR_166193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153919

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81457621..81463631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243507.4XP_011241809.1  NAD-dependent protein deacylase sirtuin-6 isoform X1

      Conserved Domains (1) summary
      cl00195
      Location:101261
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...