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    CG14543 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14543provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039404
    Locus tag
    Dmel_CG14543
    See related
    AllianceGenome:FB:FBgn0039404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14543
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 14 with mandibulofacial dysostosis. Orthologous to human TSR2 (TSR2 ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14543 in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26056630..26057350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21882352..21883072)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytidine/uridine monophosphate kinase 1 Neighboring gene Sld5 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene Ribosomal protein L34a Neighboring gene tRNA methyltransferase 61 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells. Wheeler DB, et al. Nat Methods, 2004 Nov. PMID 15782175
    2. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article
    3. Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. Buffin E, et al. PLoS One, 2010 Feb 19. PMID 20174573, Free PMC Article
    4. Genome-wide measurement of spatial expression in patterning mutants of Drosophila melanogaster. Combs PA, et al. F1000Res, 2017. PMID 28299188, Free PMC Article
    5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14543-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26056630..26057350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143201.4 → NP_651458.1  uncharacterized protein Dmel_CG14543 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBI0
      Related
      FBpp0084341
      Conserved Domains (1) summary
      pfam10273
      Location:13 → 92
      WGG; Pre-rRNA-processing protein TSR2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBI0 Q9VBI0

    Gene LinkOut

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