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    S2P site-2 protease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S2Pprovided by FlyBase
    Official Full Name
    site-2 proteaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033656
    Locus tag
    Dmel_CG8988
    See related
    AllianceGenome:FB:FBgn0033656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.346; CG8988; Dmel\CG8988; ds2p; dS2P
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein intracellular domain proteolysis and regulation of response to endoplasmic reticulum stress. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked keratosis follicularis spinulosa decalvans; X-linked mutilating palmoplantar keratoderma with periorificial keratotic plaques; ichthyosis follicularis-alopecia-photophobia syndrome 1; and osteogenesis imperfecta type 19. Orthologous to human MBTPS2 (membrane bound transcription factor peptidase, site 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See S2P in Genome Data Viewer
    Location:
    48C4-48C4; 2-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11842103..11844240, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7729608..7731745, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sine oculis-binding protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44304 Neighboring gene uncharacterized protein Neighboring gene Silnoon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The site-2 protease. Rawson RB. Biochim Biophys Acta, 2013 Dec. PMID 23571157
    2. Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning. Ordan E, et al. Biol Open, 2016 Oct 15. PMID 27628033, Free PMC Article
    3. Other ways to skin a cat: activating SREBP without Scap. Ozdemir C, et al. Fly (Austin), 2011 Jan-Mar. PMID 20935466, Free PMC Article
    4. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545, Free PMC Article
    5. The SREBP pathway--insights from Insigs and insects. Rawson RB. Nat Rev Mol Cell Biol, 2003 Aug. PMID 12923525

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein intracellular domain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    site-2 protease
    Names
    CG8988-PA
    S2P-PA
    NP_610705.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11842103..11844240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136861.4 → NP_610705.1  site-2 protease [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZ56
      Related
      FBpp0087169
      Conserved Domains (2) summary
      COG0750
      Location:136 → 508
      RseP; Membrane-associated protease RseP, regulator of RpoE activity [Posttranslational modification, protein turnover, chaperones, Transcription]
      cl10020
      Location:6 → 218
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZ56 Q7JZ56

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