U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    tsen2 tRNA splicing endonuclease subunit 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 496636, updated on 4-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tsen2provided by Xenbase
    Official Full Name
    tRNA splicing endonuclease subunit 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-5907114
    See related
    Ensembl:ENSXETG00000044211 AllianceGenome:Xenbase:XB-GENE-5907114
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    sen2; pch2b; sen2l
    Summary
    Predicted to enable lyase activity; nucleic acid binding activity; and tRNA-intron endonuclease activity. Predicted to act upstream of or within tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleus. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tsen2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (151679115..151697318)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene platelet glycoprotein IX-like Neighboring gene Yip1 domain family member 4 Neighboring gene CCHC-type zinc finger nucleic acid binding protein Neighboring gene uncharacterized LOC116410287

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_030680.2 Chromosome 4 Reference UCB_Xtro_10.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tRNA-splicing endonuclease subunit Sen2
    Names
    TSEN2 tRNA splicing endonuclease subunit
    tRNA splicing endonuclease 2 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      151679115..151697318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031901278.1 → XP_031757138.1  tRNA-splicing endonuclease subunit Sen2

      UniProtKB/TrEMBL
      A0A8J1JGY3, Q5M907
      Conserved Domains (1) summary
      cd22363
      Location:313 → 400
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    2. XM_031901276.1 → XP_031757136.1  tRNA-splicing endonuclease subunit Sen2

      UniProtKB/TrEMBL
      A0A8J1JGY3, Q5M907
      Related
      ENSXETP00000115208.1, ENSXETT00000116843.1
      Conserved Domains (1) summary
      cd22363
      Location:313 → 400
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    3. XM_031901277.1 → XP_031757137.1  tRNA-splicing endonuclease subunit Sen2

      UniProtKB/TrEMBL
      A0A8J1JGY3, Q5M907
      Conserved Domains (1) summary
      cd22363
      Location:313 → 400
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    4. XM_031901279.1 → XP_031757139.1  tRNA-splicing endonuclease subunit Sen2

      UniProtKB/TrEMBL
      A0A8J1JGY3, Q5M907
      Conserved Domains (1) summary
      cd22363
      Location:313 → 400
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.