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    LOC580047 histone-lysine N-methyltransferase NSD2 [ Strongylocentrotus purpuratus (purple sea urchin) ]

    Gene ID: 580047, updated on 14-Dec-2023

    Summary

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    Gene symbol
    LOC580047
    Gene description
    histone-lysine N-methyltransferase NSD2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Strongylocentrotus purpuratus
    Lineage
    Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae; Strongylocentrotus
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    Genomic context

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    See LOC580047 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    102 current Spur_5.0 (GCF_000002235.5) Unplaced Scaffold NW_022145600.1 (12252081..12289340)
    Build 3.1 previous assembly Spur_3.1 (GCF_000002235.3) Unplaced Scaffold NW_003578371.1 (101522..142261)

    NW_022145600.1Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 4 Neighboring gene vesicle transport protein SEC20-like Neighboring gene matrix metalloproteinase-21-like Neighboring gene uroporphyrinogen-III synthase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis. Tu Q, et al. Genome Res, 2012 Oct. PMID 22709795, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase NSD2
    Names
    histone-lysine N-methyltransferase NSD3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Strongylocentrotus purpuratus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Spur_5.0 Primary Assembly

    Genomic

    1. NW_022145600.1 Reference Spur_5.0 Primary Assembly

      Range
      12252081..12289340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030985595.1 → XP_030841455.1  histone-lysine N-methyltransferase NSD2

      UniProtKB/TrEMBL
      A0A7M7SYX2
      Conserved Domains (14) summary
      cd05837
      Location:395 → 516
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:1106 → 1201
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:852 → 937
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      COG5648
      Location:598 → 725
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:599 → 652
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      cd15567
      Location:1060 → 1100
      PHD4_NSD; PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins
      cd15568
      Location:1478 → 1520
      PHD5_NSD; PHD finger 5 found in nuclear receptor-binding SET domain-containing (NSD) proteins
      cd15648
      Location:896 → 938
      PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
      pfam03154
      Location:110 → 360
      Atrophin-1; Atrophin-1 family
      pfam15712
      Location:653 → 815
      NPAT_C; NPAT C-terminus
      pfam17907
      Location:1255 → 1293
      AWS; AWS domain
      pfam17982
      Location:1519 → 1562
      C5HCH; NSD Cys-His rich domain
      cd19173
      Location:1295 → 1436
      SET_NSD; SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins
      cl22851
      Location:991 → 1043
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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