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    DLC1 DLC1 Rho GTPase activating protein [ Rhinopithecus roxellana (golden snub-nosed monkey) ]

    Gene ID: 104672101, updated on 12-Mar-2024

    Summary

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    Gene symbol
    DLC1
    Gene description
    DLC1 Rho GTPase activating protein
    See related
    Ensembl:ENSRROG00000021290
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rhinopithecus roxellana
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus
    Orthologs
    human mouse all
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    Genomic context

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    See DLC1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    101 current ASM756505v1 (GCF_007565055.1) 9 NC_044557.1 (136978533..137429224, complement)
    100 previous assembly Rrox_v1 (GCF_000769185.1) Unplaced Scaffold NW_010818454.1 (67804..516369, complement)

    Chromosome 9 - NC_044557.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene uncharacterized LOC115899731 Neighboring gene chromosome 9 C8orf48 homolog Neighboring gene 40S ribosomal protein S3a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rhinopithecus roxellana Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM756505v1 Primary Assembly

    Genomic

    1. NC_044557.1 Reference ASM756505v1 Primary Assembly

      Range
      136978533..137429224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010375802.2 → XP_010374104.2  rho GTPase-activating protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A2K6NLK3
      Conserved Domains (3) summary
      cd08908
      Location:1315 → 1518
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:454 → 513
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:1072 → 1290
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    2. XM_030937755.1 → XP_030793615.1  rho GTPase-activating protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2K6NLL4
      Conserved Domains (2) summary
      cd08908
      Location:804 → 1007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561 → 779
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    3. XM_010375804.2 → XP_010374106.2  rho GTPase-activating protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A2K6NLK9
      Conserved Domains (3) summary
      cd08908
      Location:912 → 1115
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:51 → 110
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:669 → 887
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    4. XM_010375805.2 → XP_010374107.2  rho GTPase-activating protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A2K6NLL4
      Conserved Domains (3) summary
      cd08908
      Location:878 → 1081
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd09591
      Location:17 → 76
      SAM_DLC1; SAM domain of DLC1 subfamily
      cd04375
      Location:635 → 853
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    5. XM_010375806.2 → XP_010374108.2  rho GTPase-activating protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2K6NLL4
      Conserved Domains (2) summary
      cd08908
      Location:804 → 1007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561 → 779
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

    6. XM_010375807.2 → XP_010374109.2  rho GTPase-activating protein 7 isoform X4

      UniProtKB/TrEMBL
      A0A2K6NLL4
      Conserved Domains (2) summary
      cd08908
      Location:804 → 1007
      START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
      cd04375
      Location:561 → 779
      RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    Nucleotide Protein
    Heading Accession and Version

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