bec-1 Beclin homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bec-1
Official Full Name: Beclin homolog
Primary source: WormBase:WBGene00000247
Locus tag: CELE_T19E7.3
See related: AllianceGenome:WB:WBGene00000247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of early endosome to late endosome transport. Located in cytoplasmic vesicle and nucleus. Is expressed in several structures, including intestine; nervous system; pharyngeal-intestinal valve; pharynx; and vulva. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to several human genes including BECN1 (beclin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bec-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (5661141..5664425, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors' findings demonstrate a novel non-autonomous role for BEC-1/BECN1/Beclin1 in the control of stem cell proliferation and cell-cycle progression, which may have implications for the understanding and development of therapies against malignant cell growth in the future.
Title: A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.
Cross-talk between BEC-1 and CEP-1 protects the C. elegans genome.
Title: C. elegans CEP-1/p53 and BEC-1 are involved in DNA repair.
mutants in the gene bec-1 (VPS30/ATG6/BECN1), a key regulator of autophagy, failed to store substantial neutral lipids in their intestines during development
Title: Autophagy genes are required for normal lipid levels in C. elegans.
Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans
Title: The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.
bec-1 is an essential autophagy gene required for the longevity phenotype of the C. elegans dietary restriction mutant animal.
Title: Autophagy is required for dietary restriction-mediated life span extension in C. elegans.
Inactivation of unc-51, bec-1 and lgg-1, the worm counterparts of the yeast autophagy genes Atg1, Atg6 and Atg8 respectively, partially suppresses degeneration of neurons with toxic ion channel variants.
Title: Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
BEC-1 is necessary for the function of the class III PI3 kinase LET-512/Vps34, forms a complex with the antiapoptotic protein CED-9/Bcl-2, and its depletion triggers CED-3/Caspase-dependent programmed cell death.
Title: Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans.
essential for normal dauer morphogenesis and life-span extension
Title: Autophagy genes are essential for dauer development and life-span extension in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T19E7.3 (e-PCR)
- UniSTS:315020

T19E7.4 (e-PCR)
- UniSTS:317094

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in organelle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endosome size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Beclin homolog

NP_001368359.1

Confirmed by transcript evidence

NP_500844.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5661141..5664425 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068443.4 → NP_500844.1 Beclin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500844.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22592, V6CL88

Conserved Domains (2) summary

pfam04111
Location:63 → 366

APG6; Autophagy protein Apg6

cl19219
Location:70 → 149

DUF342; Protein of unknown function (DUF342)
NM_001380239.1 → NP_001368359.1 Beclin homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam04111
Location:3 → 113

APG6; Autophagy protein Apg6