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    trf-1 TNF Receptor Associated Factor (TRAF) homolog [ Caenorhabditis elegans ]

    Gene ID: 176767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trf-1
    Official Full Name
    TNF Receptor Associated Factor (TRAF) homolog
    Primary source
    WormBase:WBGene00006612
    Locus tag
    CELE_F45G2.6
    See related
    AllianceGenome:WB:WBGene00006612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable signaling adaptor activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be active in cytoplasm. Is expressed in tail and in male. Human ortholog(s) of this gene implicated in brain disease. Orthologous to several human genes including TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trf-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (13430462..13433438)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein Neighboring gene Exonuclease 1 Neighboring gene Coatomer subunit epsilon Neighboring gene Kunitz-type protein bli-5 Neighboring gene COMM domain-containing protein Neighboring gene Mitochondrial import inner membrane translocase subunit tim-16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Wang J, et al. Curr Biol, 2015 Dec 21. PMID 26687621, Free PMC Article
    2. A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Pujol N, et al. Curr Biol, 2001 Jun 5. PMID 11516642
    3. Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Aballay A, et al. Curr Biol, 2003 Jan 8. PMID 12526744
    4. A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. Tenor JL, et al. EMBO Rep, 2008 Jan. PMID 17975555, Free PMC Article
    5. Dissecting worm immunity. Hodgkin J. Nat Immunol, 2004 May. PMID 15116111

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TNF Receptor Associated Factor (TRAF) homolog
    NP_499773.2
    • Product from WormBase gene class trf;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13430462..13433438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067372.5 → NP_499773.2  TNF Receptor Associated Factor (TRAF) homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499773.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG80
      Conserved Domains (2) summary
      cd00270
      Location:264 → 412
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
      pfam02176
      Location:152 → 210
      zf-TRAF; TRAF-type zinc finger
    Nucleotide Protein
    Heading Accession and Version

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