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    Traip TRAF-interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Traipprovided by RGD
    Official Full Name
    TRAF-interacting proteinprovided by RGD
    Primary source
    RGD:1309761
    See related
    EnsemblRapid:ENSRNOG00000030101 AllianceGenome:RGD:1309761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; negative regulation of tumor necrosis factor-mediated signaling pathway; and replication fork processing. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 31.1), Spleen (RPKM 16.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Traip in Genome Data Viewer
    Location:
    8q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117520476..117540253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108641860..108661640)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116730170..116750528)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated Neighboring gene ubiquitin-like modifier activating enzyme 7 Neighboring gene inka box actin regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Logue SF, et al. Behav Neurosci, 1997 Feb. PMID 9109628
    2. The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Zhou Q, et al. Oncogene, 2009 Mar 12. PMID 19151749, Free PMC Article
    3. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. Zhang M, et al. J Exp Med, 2012 Sep 24. PMID 22945920, Free PMC Article
    4. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. Lee SY, et al. J Exp Med, 1997 Apr 7. PMID 9104814, Free PMC Article
    5. TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Besse A, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17544371

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRAIP
    NP_001102474.1
    XP_038937815.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109004.2 → NP_001102474.1  E3 ubiquitin-protein ligase TRAIP

      See identical proteins and their annotated locations for NP_001102474.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162006
      UniProtKB/TrEMBL
      A0A8I6GLQ9, B1WC52, F7ETT8
      Related
      ENSRNOP00000048198.3, ENSRNOT00000052289.6
      Conserved Domains (2) summary
      pfam13639
      Location:7 → 50
      zf-RING_2; Ring finger domain
      cl12013
      Location:106 → 264
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117520476..117540253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081887.2 → XP_038937815.1  E3 ubiquitin-protein ligase TRAIP isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:4 → 137
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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