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    B3galt5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 [ Mus musculus (house mouse) ]

    Gene ID: 93961, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B3galt5provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5provided by MGI
    Primary source
    MGI:MGI:2136878
    See related
    Ensembl:ENSMUSG00000074892 AllianceGenome:MGI:2136878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b3Galt-V; 1190002B21Rik
    Summary
    Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within response to bacterium. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and visual system. Orthologous to human B3GALT5 (beta-1,3-galactosyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 35.5), cerebellum adult (RPKM 6.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3galt5 in Genome Data Viewer
    Location:
    16 C4; 16 56.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (96037001..96121059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (96235801..96319859)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Leber congenital amaurosis 5-like Neighboring gene STARR-positive B cell enhancer ABC_E7483 Neighboring gene predicted gene, 53923 Neighboring gene SH3-binding domain glutamic acid-rich protein Neighboring gene STARR-seq mESC enhancer starr_41616 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96495129-96495238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96514185-96514338 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96562962-96563262 Neighboring gene predicted gene, 41510 Neighboring gene immunoglobulin superfamily, member 5 Neighboring gene integrin beta 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase. Zhou D, et al. J Biol Chem, 2000 Jul 28. PMID 10837462
    2. Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. Dunn CA, et al. Gene, 2005 Dec 30. PMID 16112824
    3. Developmental regulation of beta-1,3-galactosyltransferase-1 gene expression in mouse brain. Zhu D, et al. FEBS Lett, 2003 Mar 13. PMID 12633872
    4. Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Taniguchi M, et al. Mucosal Immunol, 2023 Oct. PMID 37385587
    5. Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. Pletcher MT, et al. Genomics, 2001 May 15. PMID 11374901

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. case study of the endogenous retrovirus long terminal repeat promoter of this enzyme, beta1,3-galactosyltransferase 5
      Title: Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,3-galactosyltransferase 5
    Names
    SSEA-3 synthase
    UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
    UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
    b3Gal-T5
    beta-1,3-GalTase 5
    beta-3-Gx-T5
    beta3Gal-T5
    beta3GalT5
    stage-specific embryonic antigen 3 synthase
    NP_001116465.1
    NP_001345318.1
    NP_001345319.1
    NP_149161.1
    XP_006523180.1
    XP_036016084.1
    XP_036016085.1
    XP_036016086.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122993.1 → NP_001116465.1  beta-1,3-galactosyltransferase 5

      See identical proteins and their annotated locations for NP_001116465.1

      Status: VALIDATED

      Source sequence(s)
      AC154258, AK004442, BC047347, BY124193
      Consensus CDS
      CCDS28356.1
      UniProtKB/Swiss-Prot
      Q9JI67
      Related
      ENSMUSP00000109431.3, ENSMUST00000113800.9
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    2. NM_001358389.1 → NP_001345318.1  beta-1,3-galactosyltransferase 5

      Status: VALIDATED

      Source sequence(s)
      AC154258, AC165170
      Consensus CDS
      CCDS28356.1
      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    3. NM_001358390.1 → NP_001345319.1  beta-1,3-galactosyltransferase 5

      Status: VALIDATED

      Source sequence(s)
      AC154258, AC165170
      Consensus CDS
      CCDS28356.1
      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    4. NM_033149.3 → NP_149161.1  beta-1,3-galactosyltransferase 5

      See identical proteins and their annotated locations for NP_149161.1

      Status: VALIDATED

      Source sequence(s)
      AC154258, AK004442, BC047347, BY124193, DN172993
      Consensus CDS
      CCDS28356.1
      UniProtKB/Swiss-Prot
      Q9JI67
      Related
      ENSMUSP00000097096.4, ENSMUST00000099497.4
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      96037001..96121059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523117.2 → XP_006523180.1  beta-1,3-galactosyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006523180.1

      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    2. XM_036160191.1 → XP_036016084.1  beta-1,3-galactosyltransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    3. XM_036160193.1 → XP_036016086.1  beta-1,3-galactosyltransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase

    4. XM_036160192.1 → XP_036016085.1  beta-1,3-galactosyltransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9JI67
      Conserved Domains (1) summary
      cl21608
      Location:69 → 259
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JI67.1 GenPept UniProtKB/Swiss-Prot:Q9JI67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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