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    Mrps17 mitochondrial ribosomal protein S17 [ Mus musculus (house mouse) ]

    Gene ID: 66258, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrps17provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S17provided by MGI
    Primary source
    MGI:MGI:1913508
    See related
    Ensembl:ENSMUSG00000034211 AllianceGenome:MGI:1913508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mprs17; 1810006P02Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and sensory organ. Orthologous to human MRPS17 (mitochondrial ribosomal protein S17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E18 (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps17 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.25 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129792514..129795776)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129715450..129718712)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 11 Neighboring gene septin 14 Neighboring gene STARR-seq mESC enhancer starr_14455 Neighboring gene STARR-positive B cell enhancer ABC_E11303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130230774-130230883 Neighboring gene nipsnap homolog 2 Neighboring gene STARR-seq mESC enhancer starr_14458 Neighboring gene STARR-seq mESC enhancer starr_14459 Neighboring gene phosphoserine phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E854

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS17m
    Names
    28S ribosomal protein S17, mitochondrial
    MRP-S17
    S17mt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356954.1 → NP_001343883.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    2. NM_001356955.1 → NP_001343884.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Related
      ENSMUSP00000112993.2, ENSMUST00000118420.8
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    3. NM_001356956.1 → NP_001343885.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Related
      ENSMUSP00000112779.2, ENSMUST00000119576.8
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    4. NM_001356957.1 → NP_001343886.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    5. NM_001356958.1 → NP_001343887.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    6. NM_001356959.1 → NP_001343888.1  small ribosomal subunit protein uS17m precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Related
      ENSMUSP00000040281.6, ENSMUST00000042191.12
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    7. NM_025450.5 → NP_079726.1  small ribosomal subunit protein uS17m precursor

      See identical proteins and their annotated locations for NP_079726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-7 all encode the same protein.
      Source sequence(s)
      AC120413, AK007356
      Consensus CDS
      CCDS19697.1
      UniProtKB/Swiss-Prot
      Q9CQE3
      Related
      ENSMUSP00000114012.2, ENSMUST00000119604.8
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    RNA

    1. NR_151584.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC120413

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129792514..129795776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254752.1 → XP_030110612.1  small ribosomal subunit protein uS17m isoform X1

      UniProtKB/Swiss-Prot
      Q9CQE3
      Related
      ENSMUSP00000114125.2, ENSMUST00000121339.2
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17

    2. XM_030254753.1 → XP_030110613.1  small ribosomal subunit protein uS17m isoform X1

      UniProtKB/Swiss-Prot
      Q9CQE3
      Conserved Domains (1) summary
      pfam00366
      Location:15 → 83
      Ribosomal_S17; Ribosomal protein S17
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQE3.1 GenPept UniProtKB/Swiss-Prot:Q9CQE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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