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    Slc22a30 solute carrier family 22, member 30 [ Mus musculus (house mouse) ]

    Gene ID: 319800, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a30provided by MGI
    Official Full Name
    solute carrier family 22, member 30provided by MGI
    Primary source
    MGI:MGI:2442750
    See related
    Ensembl:ENSMUSG00000052562 AllianceGenome:MGI:2442750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UST1R; C730048C13Rik
    Summary
    Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver adult (RPKM 28.9) See more
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    Genomic context

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    See Slc22a30 in Genome Data Viewer
    Location:
    19 A; 19 5.42 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8312735..8382475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8335371..8405111, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41804 Neighboring gene STARR-seq mESC enhancer starr_45477 Neighboring gene calpastatin pseudogene Neighboring gene predicted gene, 57826 Neighboring gene STARR-seq mESC enhancer starr_45478 Neighboring gene STARR-seq mESC enhancer starr_45479 Neighboring gene STARR-seq mESC enhancer starr_45480 Neighboring gene solute carrier family 22 (organic anion transporter), member 19 pseudogene Neighboring gene predicted gene, 57666

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane transport protein UST1R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418737.1 → NP_001405666.1  integral membrane transport protein UST1R isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166748
      UniProtKB/TrEMBL
      E9PVA5
      Related
      ENSMUSP00000069461.6, ENSMUST00000064507.12

    2. NM_177002.4 → NP_795976.1  integral membrane transport protein UST1R isoform 1

      See identical proteins and their annotated locations for NP_795976.1

      Status: VALIDATED

      Source sequence(s)
      AC166748
      Consensus CDS
      CCDS29536.1
      UniProtKB/TrEMBL
      Q8BWE8, Q8BWN6, Q96LX3
      Related
      ENSMUSP00000093988.5, ENSMUST00000096269.11
      Conserved Domains (2) summary
      cd06174
      Location:151 → 516
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8312735..8382475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527135.1 → XP_006527198.1  integral membrane transport protein UST1R isoform X1

      UniProtKB/TrEMBL
      Q8BWE8
      Conserved Domains (1) summary
      cd17374
      Location:88 → 495
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    2. XM_006527137.2 → XP_006527200.1  integral membrane transport protein UST1R isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1 → 309
      MFS; Major Facilitator Superfamily

    3. XM_006527136.2 → XP_006527199.1  integral membrane transport protein UST1R isoform X2

      See identical proteins and their annotated locations for XP_006527199.1

      UniProtKB/TrEMBL
      Q3V3G0, Q810T7
      Related
      ENSMUSP00000114071.2, ENSMUST00000120540.2
      Conserved Domains (1) summary
      cl28910
      Location:109 → 430
      MFS; Major Facilitator Superfamily

    4. XM_011247262.3 → XP_011245564.1  integral membrane transport protein UST1R isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:109 → 279
      MFS; Major Facilitator Superfamily

    5. XM_006527138.2 → XP_006527201.1  integral membrane transport protein UST1R isoform X5

      Conserved Domains (1) summary
      cl28910
      Location:109 → 275
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_877676.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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