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    Rnf17 ring finger protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 30054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf17provided by MGI
    Official Full Name
    ring finger protein 17provided by MGI
    Primary source
    MGI:MGI:1353419
    See related
    Ensembl:ENSMUSG00000000365 AllianceGenome:MGI:1353419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mmip2; TDRD4; MMIP-2
    Summary
    Enables identical protein binding activity. Acts upstream of or within spermatid development. Located in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human RNF17 (ring finger protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 6.8) and placenta adult (RPKM 0.9) See more
    Orthologs
    human all
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    Genomic context

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    See Rnf17 in Genome Data Viewer
    Location:
    14 C3; 14 28.21 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56640107..56762489)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56402650..56525032)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+/K+ transporting, nongastric, alpha polypeptide Neighboring gene STARR-seq mESC enhancer starr_36795 Neighboring gene predicted gene, 32454 Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene predicted gene, 50496 Neighboring gene predicted gene, 24392 Neighboring gene STARR-seq mESC enhancer starr_36796 Neighboring gene centromere protein J Neighboring gene STARR-positive B cell enhancer ABC_E10828 Neighboring gene STARR-positive B cell enhancer ABC_E5442 Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network. Yin XY, et al. Oncogene, 1999 Nov 18. PMID 10597267
    2. ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis. Xiong M, et al. J Cell Biol, 2023 May 1. PMID 36930220, Free PMC Article
    3. RNF17 blocks promiscuous activity of PIWI proteins in mouse testes. Wasik KA, et al. Genes Dev, 2015 Jul 1. PMID 26115953, Free PMC Article
    4. Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association. Chukrallah LG, et al. PLoS Genet, 2023 Jul. PMID 37428816, Free PMC Article
    5. RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Pan J, et al. Development, 2005 Sep. PMID 16093322, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
      Title: Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
    2. RNF17 shapes adult meiotic piRNA content by suppressing the production of secondary piRNAs
      Title: RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.
    3. RNF17 is a component of a novel germ cell nuage and is required for differentiation of male germ cells.
      Title: RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
    4. RNF17 is required for spermiogenesis in mouse. There are two RNF17 protein isoforms: RNF17L and RNF17S. RNF17 localizes to a novel nuage in germ cells.
      Title: RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 17
    Names
    Max dimerization protein member-interacting protein 2
    mad member-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033043.1 → NP_001028215.1  RING finger protein 17

      See identical proteins and their annotated locations for NP_001028215.1

      Status: PROVISIONAL

      Source sequence(s)
      AY854011
      Consensus CDS
      CCDS27149.1
      UniProtKB/Swiss-Prot
      Q3T4H2, Q3T4H3, Q4FZG6, Q8CDR4, Q99MV7, Q9QXQ2
      Related
      ENSMUSP00000093469.2, ENSMUST00000095793.3
      Conserved Domains (3) summary
      cd04508
      Location:755 → 801
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:1196 → 1312
      TUDOR; Tudor domain
      cl23765
      Location:158 → 242
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56640107..56762489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519108.3 → XP_006519171.1  RING finger protein 17 isoform X1

      Conserved Domains (2) summary
      smart00502
      Location:158 → 242
      BBC; B-Box C-terminal domain
      pfam00567
      Location:706 → 819
      TUDOR; Tudor domain

    2. XM_006519109.3 → XP_006519172.1  RING finger protein 17 isoform X2

      Conserved Domains (3) summary
      smart00502
      Location:158 → 242
      BBC; B-Box C-terminal domain
      PRK03918
      Location:87 → 273
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam00567
      Location:706 → 819
      TUDOR; Tudor domain

    3. XM_006519110.4 → XP_006519173.1  RING finger protein 17 isoform X4

      See identical proteins and their annotated locations for XP_006519173.1

      UniProtKB/Swiss-Prot
      Q99MV7
      Conserved Domains (2) summary
      smart00502
      Location:158 → 242
      BBC; B-Box C-terminal domain
      pfam00567
      Location:706 → 819
      TUDOR; Tudor domain

    4. XM_030247856.1 → XP_030103716.1  RING finger protein 17 isoform X3

      Conserved Domains (1) summary
      pfam00567
      Location:730 → 840
      TUDOR; Tudor domain

    5. XM_030247854.1 → XP_030103714.1  RING finger protein 17 isoform X3

      Conserved Domains (1) summary
      pfam00567
      Location:730 → 840
      TUDOR; Tudor domain

    6. XM_006519112.1 → XP_006519175.1  RING finger protein 17 isoform X5

      UniProtKB/Swiss-Prot
      Q99MV7
      Conserved Domains (1) summary
      pfam00567
      Location:622 → 732
      TUDOR; Tudor domain

    7. XM_030247855.1 → XP_030103715.1  RING finger protein 17 isoform X3

      Conserved Domains (1) summary
      pfam00567
      Location:730 → 840
      TUDOR; Tudor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MV7.2 GenPept UniProtKB/Swiss-Prot:Q99MV7

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