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    Nav1 neuron navigator 1 [ Mus musculus (house mouse) ]

    Gene ID: 215690, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nav1provided by MGI
    Official Full Name
    neuron navigator 1provided by MGI
    Primary source
    MGI:MGI:2183683
    See related
    Ensembl:ENSMUSG00000009418 AllianceGenome:MGI:2183683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm38399; Pomfil3; Unc53h1; mKIAA1151; steerin-1; 9530089B19; 9930003A20Rik; C230080M11Rik
    Summary
    Predicted to enable ATP hydrolysis activity. Acts upstream of or within microtubule bundle formation and neuron migration. Located in axon initial segment and microtubule cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; molar; peripheral nervous system ganglion; and sensory organ. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 16.8), whole brain E14.5 (RPKM 14.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nav1 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135362318..135616082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135434580..135688350, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene shisa family member 4 Neighboring gene STARR-seq mESC enhancer starr_02365 Neighboring gene importin 9 Neighboring gene STARR-positive B cell enhancer ABC_E10038 Neighboring gene microRNA 1231 Neighboring gene STARR-seq mESC enhancer starr_02370 Neighboring gene STARR-seq mESC enhancer starr_02371 Neighboring gene predicted gene, 32940 Neighboring gene predicted gene 4793 Neighboring gene STARR-seq mESC enhancer starr_02376 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene pleckstrin homology like domain, family A, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice. Bagley JR, et al. Commun Biol, 2023 Oct 18. PMID 37853211, Free PMC Article
    2. The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility. Sánchez-Huertas C, et al. J Cell Biol, 2020 Sep 7. PMID 32497170, Free PMC Article
    3. Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1. Powers RM, et al. Mol Biol Cell, 2022 Jun 1. PMID 35352947, Free PMC Article
    4. Na(v)1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Fu W, et al. Nature, 2024 Jan. PMID 38172636, Free PMC Article
    5. Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration. Martínez-López MJ, et al. Mol Cell Neurosci, 2005 Apr. PMID 15797708

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon initial segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuron navigator 1
    Names
    Steerin1
    pore membrane and/or filament-interacting-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427516.1 → NP_001414445.1  neuron navigator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC016814, AC120396, AC120405, AC162441

    2. NM_173437.2 → NP_775613.2  neuron navigator 1 isoform 2

      See identical proteins and their annotated locations for NP_775613.2

      Status: VALIDATED

      Source sequence(s)
      AC016814, AK122458, AK140435, AK153742, CB523329, CN455316
      Consensus CDS
      CCDS35720.1
      UniProtKB/Swiss-Prot
      Q3U5B6, Q68EE8, Q6PB78, Q80TI7, Q8BKG2, Q8BUT5, Q8CH77
      UniProtKB/TrEMBL
      A0A589P973
      Related
      ENSMUSP00000067241.7, ENSMUST00000067414.13
      Conserved Domains (2) summary
      cd00009
      Location:1552 → 1659
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:1548 → 1659
      AAA; ATPases associated with a variety of cellular activities

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135362318..135616082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252963.1 → XP_030108823.1  neuron navigator 1 isoform X12

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (2) summary
      smart00382
      Location:1561 → 1672
      AAA; ATPases associated with a variety of cellular activities
      TIGR02168
      Location:1090 → 1174
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_030252962.2 → XP_030108822.1  neuron navigator 1 isoform X11

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1564 → 1675
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:10 → 260
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1093 → 1177
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006529378.4 → XP_006529441.1  neuron navigator 1 isoform X10

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1581 → 1692
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1110 → 1194
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_036163515.1 → XP_036019408.1  neuron navigator 1 isoform X9

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1780 → 1891
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1315 → 1396
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_006529377.4 → XP_006529440.1  neuron navigator 1 isoform X8

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1783 → 1894
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR04211
      Location:1315 → 1394
      SH3_and_anchor; SH3 domain protein

    6. XM_006529376.4 → XP_006529439.1  neuron navigator 1 isoform X7

      UniProtKB/TrEMBL
      A0A589P973
      Related
      ENSMUSP00000140322.3, ENSMUST00000190298.8
      Conserved Domains (3) summary
      smart00382
      Location:1788 → 1899
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1320 → 1404
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_006529375.4 → XP_006529438.1  neuron navigator 1 isoform X6

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1791 → 1902
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1320 → 1404
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_006529373.4 → XP_006529436.1  neuron navigator 1 isoform X4

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1837 → 1948
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR04211
      Location:1372 → 1451
      SH3_and_anchor; SH3 domain protein

    9. XM_006529372.4 → XP_006529435.1  neuron navigator 1 isoform X3

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1840 → 1951
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR04211
      Location:1372 → 1451
      SH3_and_anchor; SH3 domain protein

    10. XM_006529371.4 → XP_006529434.1  neuron navigator 1 isoform X2

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1845 → 1956
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1377 → 1461
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. XM_006529369.4 → XP_006529432.1  neuron navigator 1 isoform X1

      See identical proteins and their annotated locations for XP_006529432.1

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1848 → 1959
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1377 → 1461
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_006529370.4 → XP_006529433.1  neuron navigator 1 isoform X1

      See identical proteins and their annotated locations for XP_006529433.1

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1848 → 1959
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1377 → 1461
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_017319805.2 → XP_017175294.1  neuron navigator 1 isoform X1

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1848 → 1959
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:27 → 277
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1377 → 1461
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. XM_017319809.1 → XP_017175298.1  neuron navigator 1 isoform X5

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (3) summary
      smart00382
      Location:1831 → 1942
      AAA; ATPases associated with a variety of cellular activities
      PHA03247
      Location:10 → 260
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:1360 → 1444
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_006529379.4 → XP_006529442.1  neuron navigator 1 isoform X12

      UniProtKB/TrEMBL
      A0A589P973
      Conserved Domains (2) summary
      smart00382
      Location:1561 → 1672
      AAA; ATPases associated with a variety of cellular activities
      TIGR02168
      Location:1090 → 1174
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_006529380.5 → XP_006529443.1  neuron navigator 1 isoform X13

      Conserved Domains (2) summary
      smart00382
      Location:1154 → 1265
      AAA; ATPases associated with a variety of cellular activities
      TIGR02168
      Location:683 → 767
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004941778.1 RNA Sequence

    2. XR_003954495.1 RNA Sequence

    3. XR_878320.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH77.2 GenPept UniProtKB/Swiss-Prot:Q8CH77

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