PAE2 20S proteasome alpha subunit E2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PAE2
Official Full Name: 20S proteasome alpha subunit E2
Primary source: TAIR:AT3G14290
Locus tag: AT3G14290
See related: Araport:AT3G14290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 20S proteasome alpha subunit E2; 20S PROTEASOME SUBUNIT PAE2
Summary: Encodes 20S proteasome subunit PAE2 (PAE2) that has RNase activity.
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Genomic context

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See PAE2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (4764024..4766609)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results extend to A. thaliana alpha(5) the range of HcPro-interacting proteasomal subunits, and suggest that HcPro may modulate its associated RNase activity which may contribute to an antiviral response.
Title: The 20S proteasome α5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the lettuce mosaic potyvirus HcPro protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112287.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	TAS Traceable Author Statement more info	PubMed
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 20S proteasome alpha subunit E2

NP_188046.1

20S proteasome alpha subunit E2 (PAE2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit E1 (TAIR:AT1G53850.2); Has 8015 Blast hits to 8011 proteins in 570 species: Archae - 901; Bacteria - 216; Metazoa - 2770; Fungi - 1923; Plants - 1008; Viruses - 0; Other Eukaryotes - 1197 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

4764024..4766609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112287.4 → NP_188046.1 20S proteasome alpha subunit E2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q42134

UniProtKB/TrEMBL

A0A178VCX2, A0A5S9XC18, A0A654F8R2

Conserved Domains (1) summary

cd03753
Location:8 → 218

proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...