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    Msl3 MSL complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 17692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msl3provided by MGI
    Official Full Name
    MSL complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1341851
    See related
    Ensembl:ENSMUSG00000031358 AllianceGenome:MGI:1341851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl31; Msl3l1
    Summary
    Predicted to enable DNA binding activity; histone reader activity; and methylated histone binding activity. Involved in positive regulation of DNA-templated transcription. Part of MSL complex. Is expressed in cerebral cortex ventricular layer; embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in Basilicata-Akhtar syndrome. Orthologous to human MSL3 (MSL complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.1), placenta adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msl3 in Genome Data Viewer
    Location:
    X F5; X 78.73 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (167434263..167456868, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (168651267..168674354, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_48277 Neighboring gene predicted pseudogene 7209 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165110350-165110651 Neighboring gene STARR-seq mESC enhancer starr_48278 Neighboring gene predicted gene, 39550 Neighboring gene STARR-seq mESC enhancer starr_48279 Neighboring gene Rho GTPase activating protein 6 Neighboring gene STARR-seq mESC enhancer starr_48280 Neighboring gene STARR-positive B cell enhancer mm9_chrX:165523946-165524246 Neighboring gene STARR-seq mESC enhancer starr_48281 Neighboring gene amelogenin, X-linked Neighboring gene holocytochrome c synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents. Mitchell TA, et al. Dev Dyn, 2024 May. PMID 37847071,
    2. Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3. Prakash SK, et al. Genomics, 1999 Jul 1. PMID 10395802
    3. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice. Cormier TA, et al. Mamm Genome, 2001 Oct. PMID 11668396
    4. Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Wolstenholme JT, et al. Genes Brain Behav, 2013 Mar. PMID 23210685, Free PMC Article
    5. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Kadlec J, et al. Nat Struct Mol Biol, 2011 Feb. PMID 21217699

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.
      Title: Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.
    2. Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3).
      Title: PEG3 control on the mammalian MSL complex.
    3. Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.
      Title: Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.
    4. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
      Title: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MSL complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MSL complex subunit 3; male-specific lethal 3 homolog
    Names
    male-specific lethal-3 homolog 1
    male-specific lethal-3 protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370791.1 → NP_001357720.1  MSL complex subunit 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Consensus CDS
      CCDS90775.1
      UniProtKB/Swiss-Prot
      B1AUJ7, B1AUJ8, Q9WVG9
      Related
      ENSMUSP00000033725.10, ENSMUST00000033725.16
      Conserved Domains (3) summary
      cd18983
      Location:15 → 81
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:176 → 510
      MRG
      pfam12258
      Location:313 → 412
      Microcephalin; Microcephalin protein

    2. NM_001370792.1 → NP_001357721.1  MSL complex subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      cd18983
      Location:15 → 81
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:175 → 509
      MRG
      pfam12258
      Location:312 → 411
      Microcephalin; Microcephalin protein

    3. NM_001370793.1 → NP_001357722.1  MSL complex subunit 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:154 → 488
      MRG
      pfam12258
      Location:291 → 390
      Microcephalin; Microcephalin protein
      cl28914
      Location:12 → 59
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    4. NM_001370794.1 → NP_001357723.1  MSL complex subunit 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      cd18983
      Location:15 → 81
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:175 → 499
      MRG
      pfam12258
      Location:312 → 411
      Microcephalin; Microcephalin protein

    5. NM_001370795.1 → NP_001357724.1  MSL complex subunit 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:116 → 450
      MRG
      pfam12258
      Location:253 → 352
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    6. NM_001370796.1 → NP_001357725.1  MSL complex subunit 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:117 → 441
      MRG
      pfam12258
      Location:254 → 353
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    7. NM_001370797.1 → NP_001357726.1  MSL complex subunit 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:116 → 440
      MRG
      pfam12258
      Location:253 → 352
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    8. NM_001370798.1 → NP_001357727.1  MSL complex subunit 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:120 → 426
      MRG
      pfam12258
      Location:229 → 328
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    9. NM_001370799.1 → NP_001357728.1  MSL complex subunit 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:117 → 241
      MRG
      pfam12258
      Location:254 → 353
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    10. NM_001411770.1 → NP_001398699.1  MSL complex subunit 3 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL671489

    11. NM_001411771.1 → NP_001398700.1  MSL complex subunit 3 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL671489

    12. NM_001411772.1 → NP_001398701.1  MSL complex subunit 3 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL671489

    13. NM_010832.6 → NP_034962.2  MSL complex subunit 3 isoform 5

      See identical proteins and their annotated locations for NP_034962.2

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Consensus CDS
      CCDS41211.1
      UniProtKB/Swiss-Prot
      Q9WVG9
      Related
      ENSMUSP00000107765.2, ENSMUST00000112137.2
      Conserved Domains (3) summary
      pfam05712
      Location:117 → 451
      MRG
      pfam12258
      Location:254 → 353
      Microcephalin; Microcephalin protein
      cl28914
      Location:3 → 22
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      167434263..167456868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161839.1 → XP_036017732.1  male-specific lethal 3 homolog isoform X4

      Conserved Domains (1) summary
      pfam05712
      Location:5 → 340
      MRG
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVG9.3 GenPept UniProtKB/Swiss-Prot:Q9WVG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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