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    CSAG3 CSAG family member 3 [ Homo sapiens (human) ]

    Gene ID: 389903, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CSAG3provided by HGNC
    Official Full Name
    CSAG family member 3provided by HGNC
    Primary source
    HGNC:HGNC:26237
    See related
    Ensembl:ENSG00000268916 MIM:301097; AllianceGenome:HGNC:26237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSAG3A; CT24.2
    Summary
    Predicted to be involved in response to xenobiotic stimulus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 1.6), lymph node (RPKM 1.1) and 5 other tissues See more
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    Genomic context

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    See CSAG3 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152753921..152760219)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151020472..151026772)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_003871103.3 (187904..194202)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:151902449-151903648 Neighboring gene MAGE family member A12 Neighboring gene CSAG family member 4 (pseudogene) Neighboring gene MAGE family member A2 Neighboring gene MAGE family member A6 Neighboring gene MAGEA6 divergent transcript Neighboring gene MAGE family member A4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors. Yao X, et al. Cancer Genet Cytogenet, 2004 May. PMID 15120907
    2. TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. Duan Z, et al. Gene, 1999 Mar 18. PMID 10095106
    3. TRAG-3, a novel cancer/testis antigen, is overexpressed in the majority of melanoma cell lines and malignant melanoma. Feller AJ, et al. Anticancer Res, 2000 Nov-Dec. PMID 11205240
    4. Expression of TRAG-3 antigen in non-small-cell lung carcinomas. Chen Z, et al. Lung Cancer, 2002 Oct. PMID 12367802
    5. Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2' deoxyazacytidine. Zhu B, et al. Lung Cancer, 2002 Dec. PMID 12445756

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC17065, MGC149851, MGC149852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to xenobiotic stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chondrosarcoma-associated gene 2/3 protein
    Names
    CSAG family, member 3A
    cancer/testis antigen 24.2
    taxol resistance associated gene 3
    taxol-resistant-associated gene 3 protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129826.3 → NP_001123298.1  chondrosarcoma-associated gene 2/3 protein isoform a

      See identical proteins and their annotated locations for NP_001123298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as TRAG-3L) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC244102
      UniProtKB/Swiss-Prot
      O75605, Q0VDC3, Q96IU8, Q9Y5P2
      Related
      ENSP00000491011.1, ENST00000599845.3

    2. NM_001129828.3 → NP_001123300.1  chondrosarcoma-associated gene 2/3 protein isoform b

      See identical proteins and their annotated locations for NP_001123300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as TRAG-3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC244102, BC007228, BC119735
      UniProtKB/Swiss-Prot
      Q9Y5P2
      Related
      ENSP00000492276.1, ENST00000638835.1

    RNA

    1. NR_130638.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' exon structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC244102, BC007228
      Related
      ENST00000617158.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152753921..152760219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452379.2 → XP_024308147.1  chondrosarcoma-associated gene 2/3 protein isoform X1

      UniProtKB/Swiss-Prot
      O75605, Q0VDC3, Q96IU8, Q9Y5P2

    2. XM_047442103.1 → XP_047298059.1  chondrosarcoma-associated gene 2/3 protein isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791818.1 Reference GRCh38.p14 PATCHES

      Range
      323392..329684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151020472..151026772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327046.1 → XP_054183021.1  chondrosarcoma-associated gene 2/3 protein isoform X1

      UniProtKB/TrEMBL
      A0A1W2PPV0

    2. XM_054327047.1 → XP_054183022.1  chondrosarcoma-associated gene 2/3 protein isoform X2

      UniProtKB/TrEMBL
      A0A1W2PQG5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203311.1: Suppressed sequence

      Description
      NM_203311.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5P2.2 GenPept UniProtKB/Swiss-Prot:Q9Y5P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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