CMKLR1 chemerin chemokine-like receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CMKLR1provided by HGNC
Official Full Name: chemerin chemokine-like receptor 1provided by HGNC
Primary source: HGNC:HGNC:2121
See related: Ensembl:ENSG00000174600 MIM:602351; AllianceGenome:HGNC:2121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DEZ; ERV1; RVER1; ChemR23; CHEMERINR
Summary: Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (108288046..108339311, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (108256268..108307509, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (108681823..108733088, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
Title: GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
Title: Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
Title: Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
Title: ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
[Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
Title: [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
Title: Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
Title: Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
Title: Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
Title: Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
Title: The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of chemokine-like receptor 1 (CMKLR1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S1605 (e-PCR), detects polymorphism
- UniSTS:26660

NoName (e-PCR)
- UniSTS:486462

STS-U79526 (e-PCR)
- UniSTS:70783

RH47923 (e-PCR)
- UniSTS:8359

NoName (e-PCR)
- UniSTS:482503

NoName (e-PCR)
- UniSTS:481497

G59772 (e-PCR)
- UniSTS:136925

SHGC-152880 (e-PCR)
- UniSTS:182250

G54197 (e-PCR)
- UniSTS:109555

G54199 (e-PCR)
- UniSTS:109557

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables adipokinetic hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables adipokinetic hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal system development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: chemerin-like receptor 1

Names: G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; chemerin receptor; chemokine receptor-like 1; chemokine-like receptor 1; orphan G-protein coupled receptor, Dez; resolvin E1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142343.2 → NP_001135815.1 chemerin-like receptor 1 isoform a

See identical proteins and their annotated locations for NP_001135815.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC009729, AC063957, BC106927, DA466082

Consensus CDS

CCDS44965.1

UniProtKB/Swiss-Prot

A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789

UniProtKB/TrEMBL

Q05KQ8

Related

ENSP00000449716.1, ENST00000550402.6

Conserved Domains (1) summary

cd15116
Location:41 → 327

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001142344.2 → NP_001135816.1 chemerin-like receptor 1 isoform a

See identical proteins and their annotated locations for NP_001135816.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes isoform a.

Source sequence(s)

AC009729, AC063957, AK291800

Consensus CDS

CCDS44965.1

UniProtKB/Swiss-Prot

A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789

UniProtKB/TrEMBL

Q05KQ8

Related

ENSP00000311733.7, ENST00000312143.11

Conserved Domains (1) summary

cd15116
Location:41 → 327

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001142345.2 → NP_001135817.1 chemerin-like receptor 1 isoform a

See identical proteins and their annotated locations for NP_001135817.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes isoform a.

Source sequence(s)

AC009729, AC063957, DA939526

Consensus CDS

CCDS44965.1

UniProtKB/Swiss-Prot

A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789

UniProtKB/TrEMBL

Q05KQ8

Related

ENSP00000401293.1, ENST00000412676.5

Conserved Domains (1) summary

cd15116
Location:41 → 327

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_004072.3 → NP_004063.1 chemerin-like receptor 1 isoform b

See identical proteins and their annotated locations for NP_004063.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a.

Source sequence(s)

AC009729, DA466082, U79527

Consensus CDS

CCDS41829.1

UniProtKB/TrEMBL

Q05KQ8

Related

ENSP00000447579.1, ENST00000552995.5

Conserved Domains (1) summary

pfam00001
Location:55 → 314

7tm_1; 7 transmembrane receptor (rhodopsin family)