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    DRG2 developmentally regulated GTP binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 1819, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DRG2provided by HGNC
    Official Full Name
    developmentally regulated GTP binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:3030
    See related
    Ensembl:ENSG00000108591 MIM:602986; AllianceGenome:HGNC:3030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DRG2 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18087948..18107969)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18034778..18054782)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17991262..18011283)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene GID complex subunit 4 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18053522-18054022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18056260-18056783

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. G proteins, effectors and GAPs: structure and mechanism. Sprang SR. Curr Opin Struct Biol, 1997 Dec. PMID 9434906
    2. Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13-->p12 by in situ hybridization. Schenker T, et al. Cytogenet Cell Genet, 1997. PMID 9605870
    3. Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval. Vlangos CN, et al. Cytogenet Cell Genet, 2000. PMID 10828610
    4. Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis. Song H, et al. J Biochem, 2004 Mar. PMID 15113831
    5. DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells. Dang T, et al. Mol Cells, 2018 Dec 31. PMID 30453731, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
      Title: Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
    2. Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
      Title: Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
    3. Developmentally regulated GTPases: structure, function and roles in disease.
      Title: Developmentally regulated GTPases: structure, function and roles in disease.
    4. DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
      Title: DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
    5. Knockdown of DRG2 in HeLa cells treated with epidermal growth factor (EGF) affects microtubule dynamics, perinuclear Golgi stacking, and cell migration.
      Title: DRG2 knockdown induces Golgi fragmentation via GSK3β phosphorylation and microtubule stabilization.
    6. Using immunoprecipitation, authors show that DRG2 interacts with tau, which regulates microtubule polymerization. Collectively, these data demonstrate that DRG2 may aid in affecting microtubule dynamics in HeLa cells.
      Title: DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
    7. Results show that the SNP (rs2257609 C>T) located in the intron region of SLC5A10 variant does not affect the expression of SLC5A10 mRNA, but alters the mRNA expression and promoter activity of DRG2. It is significantly associated with worse overall and disease-free survival of non-small-cell lung cancer (NSCLC) patients.
      Title: Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early-stage non-small-cell lung cancer.
    8. Taken together, our data demonstrate that DRG2 acts as a regulator of mitochondrial fission by controlling the expression of Drp1.
      Title: Developmentally regulated GTP-binding protein 2 depletion leads to mitochondrial dysfunction through downregulation of dynamin-related protein 1.
    9. Authors observed that knockdown of DRG2 in HeLa cells affected growth in a wound-healing assay, and tumorigenicity in nude mice xenografts.
      Title: DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.
    10. Results demonstrate that DRG2 is an endosomal protein and a key regulator of Rab5 deactivation and Tfn recycling.
      Title: Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    developmentally-regulated GTP-binding protein 2
    Names
    TRAFAC GTPase DRG2
    translation factor GTPase DRG2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330144.2 → NP_001317073.1  developmentally-regulated GTP-binding protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087164
      Consensus CDS
      CCDS82082.1
      UniProtKB/TrEMBL
      A8MZF9
      Related
      ENSP00000379076.4, ENST00000395726.8
      Conserved Domains (4) summary
      cd01896
      Location:63 → 295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1 → 331
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl00155
      Location:289 → 331
      UBQ; Ubiquitin-like proteins
      cl21455
      Location:3 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001388.5 → NP_001379.1  developmentally-regulated GTP-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001379.1

      Status: REVIEWED

      Source sequence(s)
      BC000493, DA602486, X80754
      Consensus CDS
      CCDS11191.1
      UniProtKB/Swiss-Prot
      B2R8G5, P55039, Q53Y50, Q9BWB2
      Related
      ENSP00000225729.3, ENST00000225729.8
      Conserved Domains (4) summary
      cd01666
      Location:289 → 363
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:63 → 295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1 → 364
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:3 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      18087948..18107969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256499.4 → XP_005256556.1  developmentally-regulated GTP-binding protein 2 isoform X1

      Conserved Domains (4) summary
      cd01666
      Location:289 → 384
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:63 → 295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1 → 385
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:3 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_011523704.3 → XP_011522006.1  developmentally-regulated GTP-binding protein 2 isoform X2

      Conserved Domains (4) summary
      cd01896
      Location:63 → 295
      DRG; Developmentally Regulated GTP-binding protein (DRG)
      COG1163
      Location:1 → 352
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
      cl00155
      Location:289 → 352
      UBQ; Ubiquitin-like proteins
      cl21455
      Location:3 → 119
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_005256500.3 → XP_005256557.1  developmentally-regulated GTP-binding protein 2 isoform X3

      Conserved Domains (2) summary
      cd01666
      Location:208 → 303
      TGS_DRG_C; TGS_DRG_C: DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it ...
      cd01896
      Location:1 → 214
      DRG; Developmentally Regulated GTP-binding protein (DRG)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      18034778..18054782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315305.1 → XP_054171280.1  developmentally-regulated GTP-binding protein 2 isoform X1

    2. XM_054315306.1 → XP_054171281.1  developmentally-regulated GTP-binding protein 2 isoform X2

    3. XM_054315307.1 → XP_054171282.1  developmentally-regulated GTP-binding protein 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55039.1 GenPept UniProtKB/Swiss-Prot:P55039

    Gene LinkOut

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