CSD1 copper/zinc superoxide dismutase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CSD1
Official Full Name: copper/zinc superoxide dismutase 1
Primary source: TAIR:AT1G08830
Locus tag: AT1G08830
See related: Araport:AT1G08830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSOD1; copper/zinc superoxide dismutase 1; F22O13.32; F22O13_32; SOD1; superoxide dismutase 1
Summary: Encodes a cytosolic copper/zinc superoxide dismutase CSD1 that can detoxify superoxide radicals. Its expression is affected by miR398-directed mRNA cleavage. Regulated by biotic and abiotic stress. Activation of CSD1 in the cytoplasm involves both a CCS-dependent and -independent pathway.
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Genomic context

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See CSD1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (2827060..2829315)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a series of grafting experiments using spl7 mutant and wild-type (WT) plants, expression of Cu-responsive microRNAs and the resulting suppression of CSD1 and CSD2 mRNAs were observed in leaves only when the aerial part was from WT plants, in which a low level of SPL7 was transcribed also in the vascular tissues.
Title: SPL7 locally regulates copper-homeostasis-related genes in Arabidopsis.
An Arabidopsis Cu/ZnSOD isoform maintained high activity in the shoot of the SUMO E3 ligase mutant siz1 under normal conditions. Reduced CSD1 protein accumulation and activity under excess Cu treatment suggests that Cu-induced SUMOylation participates in the control of CSD1 protein stability.[CSD1]
Title: Effect of Cu content on the activity of Cu/ZnSOD1 in the Arabidopsis SUMO E3 ligase siz1 mutant.
Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.
Title: The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 as well as the activation of MKK5 activity were completely arrested.
Title: MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis.
Data indicate that transgenic plants expressing miR398-resistant forms of CSD1, CSD2 and CCS under the control of their native promoters are more sensitive to heat stress.
Title: Heat stress induction of miR398 triggers a regulatory loop that is critical for thermotolerance in Arabidopsis.
Results show that CSD1, but not CSD2, mRNA levels were negatively correlated with miR398 levels during ozone, salinity and biotic stress.
Title: Biotic and abiotic stress down-regulate miR398 expression in Arabidopsis.
Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases.
Title: Sucrose induction of Arabidopsis miR398 represses two Cu/Zn superoxide dismutases.
CSD1 expression is fine-tuned by miR398-directed mRNA cleavage.
Title: Posttranscriptional induction of two Cu/Zn superoxide dismutase genes in Arabidopsis is mediated by downregulation of miR398 and important for oxidative stress tolerance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084025.1

Supported by ESTs:

NM_100757.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to UV-B	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sucrose stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to ozone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: copper/zinc superoxide dismutase 1

NP_001077494.1

copper/zinc superoxide dismutase 1 (CSD1); CONTAINS InterPro DOMAIN/s: Superoxide dismutase, copper/zinc, binding site (InterPro:IPR018152), Superoxide dismutase, copper/zinc binding (InterPro:IPR001424); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 2 (TAIR:AT2G28190.1); Has 4705 Blast hits to 4689 proteins in 1491 species: Archae - 6; Bacteria - 2000; Metazoa - 1249; Fungi - 303; Plants - 666; Viruses - 142; Other Eukaryotes - 339 (source: NCBI BLink).

NP_172360.1

copper/zinc superoxide dismutase 1 (CSD1); FUNCTIONS IN: superoxide dismutase activity; INVOLVED IN: in 7 processes; LOCATED IN: cytosol, cytoplasm; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Superoxide dismutase, copper/zinc, binding site (InterPro:IPR018152), Superoxide dismutase, copper/zinc binding (InterPro:IPR001424); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 2 (TAIR:AT2G28190.1); Has 4705 Blast hits to 4689 proteins in 1491 species: Archae - 6; Bacteria - 2000; Metazoa - 1249; Fungi - 303; Plants - 666; Viruses - 142; Other Eukaryotes - 339 (source: NCBI BLink).