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    NSN1 GTP-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819890, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NSN1
    Official Full Name
    GTP-binding family protein
    Primary source
    TAIR:AT3G07050
    Locus tag
    AT3G07050
    See related
    Araport:AT3G07050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    nucleostemin-like 1
    Summary
    Arabidopsis NSN1 encodes a nucleolar GTP- binding protein and is required for maintenance of inflorescence meristem identity and floral organ development.
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    Genomic context

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    See NSN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (2229355..2232361, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene Alba DNA/RNA-binding protein Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene tRNA-Met Neighboring gene NHL domain-containing protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) regulates cell cycling potentially by cooperating with nucleosome assembly protein AtNAP1;1. Wang Z, et al. BMC Plant Biol, 2018 Jun 1. PMID 29859040, Free PMC Article
    2. Nucleostemin-like 1 is required for embryogenesis and leaf development in Arabidopsis. Wang X, et al. Plant Mol Biol, 2012 Jan. PMID 22058024
    3. Signaling by the EPFL-ERECTA family coordinates female germline specification through the BZR1 family in Arabidopsis. Cai H, et al. Plant Cell, 2023 Apr 20. PMID 36748257, Free PMC Article
    4. The nucleolar GTPase nucleostemin-like 1 plays a role in plant growth and senescence by modulating ribosome biogenesis. Jeon Y, et al. J Exp Bot, 2015 Oct. PMID 26163696, Free PMC Article
    5. A nucleostemin-like GTPase required for normal apical and floral meristem development in Arabidopsis. Wang X, et al. Mol Biol Cell, 2012 Apr. PMID 22357616, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSN1 was found to function as a positive regulator in cell cycle progression. The interaction between NSN1 and histone chaperone AtNAP1;1, and the high resemblance in sensitivity to genotoxics between nsn1 and atnap1;1 imply the indispensability of the two nuclear proteins for cell cycle regulation.
      Title: Arabidopsis NUCLEOSTEMIN-LIKE 1 (NSN1) regulates cell cycling potentially by cooperating with nucleosome assembly protein AtNAP1;1.
    2. in the delicately balanced regulatory network, NSN1 acts to repress AG and plays an additive role with AP2 in floral organ specification.
      Title: A nucleostemin-like GTPase required for normal apical and floral meristem development in Arabidopsis.
    3. Results demonstrate that AT3G07050 (NSN1, NUCLEOSTEMIN-LIKE 1) represents a novel GTPase required for embryogenesis, leaf development and leaf polarity.
      Title: Nucleostemin-like 1 is required for embryogenesis and leaf development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111585.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of inflorescence meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    GTP-binding family protein
    NP_187361.1
    • GTP-binding family protein; FUNCTIONS IN: GTP binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleolus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Small GTP-binding protein (InterPro:IPR005225), GTP1/OBG (InterPro:IPR006073), GTP-binding protein, HSR1-related (InterPro:IPR002917), GNL3L/Grn1 putative GTPase (InterPro:IPR014813); BEST Arabidopsis thaliana protein match is: GTP-binding family protein (TAIR:AT1G52980.1); Has 11622 Blast hits to 10428 proteins in 1861 species: Archae - 158; Bacteria - 5948; Metazoa - 1715; Fungi - 910; Plants - 502; Viruses - 28; Other Eukaryotes - 2361 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2229355..2232361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111585.5 → NP_187361.1  GTP-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93Y17, Q9M8Z5
      UniProtKB/TrEMBL
      A0A178VBD5, A0A654F6I4
      Conserved Domains (3) summary
      cd04178
      Location:138 → 308
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      TIGR00231
      Location:254 → 390
      small_GTP; small GTP-binding protein domain
      pfam08701
      Location:44 → 91
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8Z5.1

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