MSL2 MSCS-like 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MSL2
Official Full Name: MSCS-like 2
Primary source: TAIR:AT5G10490
Locus tag: AT5G10490
See related: Araport:AT5G10490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F12B17.160; F12B17_160; MSCS-like 2
Summary: A member of MscS-like gene family, structurally very similar to MSL3, comprising of an N-terminal chloroplast transit peptide, five trans-membrane helices and a C-terminal cytoplasmic domain. Mutant plants showed abnormalities in the size and shape of plastids. MSL2-GFP was localized to discrete foci on the plastid envelope and co-localize with the plastid division protein AtMinE.
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Genomic context

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See MSL2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 14

Sequence:: Chromosome: 5; NC_003076.8 (3300192..3304784, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for partial functional overlap of KEA and MSL transport proteins in the chloroplast inner envelope of Arabidopsis thaliana.
Title: Evidence for partial functional overlap of KEA and MSL transport proteins in the chloroplast inner envelope of Arabidopsis thaliana.
Two of the three conserved motifs are critical for MSL2 function, consistent with the conservation of structure and function between MscS family members in bacteria and plants.
Title: Functional analysis of conserved motifs in the mechanosensitive channel homolog MscS-Like2 from Arabidopsis thaliana.
MSL2, MSL3, and components of the Min system function in the same pathway to regulate chloroplast size and FtsZ ring formation.
Title: Two mechanosensitive channel homologs influence division ring placement in Arabidopsis chloroplasts.
We conclude that plastids are under hypoosmotic stress during normal plant growth and dynamic response to this stress requires MSL2 and MSL3.
Title: Mechanosensitive channels protect plastids from hypoosmotic stress during normal plant growth.
Two MscS-like proteins, MSL2 and MSL3, alter ion flux in response to changes in membrane tension to regulate plastid size, shape, and perhaps division during normal plant development. [MSL2]
Title: MscS-like proteins control plastid size and shape in Arabidopsis thaliana.

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General gene information

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NM_001203349.1

Supported by ESTs:

NM_121087.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast fission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plastid organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plastid envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MSCS-like 2

NP_001078567.1

MSCS-like 2 (MSL2); FUNCTIONS IN: ion channel activity; INVOLVED IN: plastid organization; LOCATED IN: chloroplast, membrane, plastid envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: MSCS-like 3 (TAIR:AT1G58200.2); Has 4285 Blast hits to 4245 proteins in 1032 species: Archae - 175; Bacteria - 2256; Metazoa - 237; Fungi - 57; Plants - 186; Viruses - 3; Other Eukaryotes - 1371 (source: NCBI BLink).

NP_001190278.1

MSCS-like 2 (MSL2); CONTAINS InterPro DOMAIN/s: Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920), Mechanosensitive ion channel MscS (InterPro:IPR006685); BEST Arabidopsis thaliana protein match is: MSCS-like 3 (TAIR:AT1G58200.2).

NP_568230.2

MSCS-like 2 (MSL2); FUNCTIONS IN: ion channel activity; INVOLVED IN: plastid organization; LOCATED IN: chloroplast, membrane, plastid envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: MSCS-like 3 (TAIR:AT1G58200.2); Has 4292 Blast hits to 4247 proteins in 1034 species: Archae - 175; Bacteria - 2259; Metazoa - 236; Fungi - 59; Plants - 186; Viruses - 3; Other Eukaryotes - 1374 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

3300192..3304784 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001085098.2 → NP_001078567.1 MSCS-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078567.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3L1

Conserved Domains (2) summary

COG0668
Location:131 → 448

MscS; Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis]

pfam00924
Location:216 → 408

MS_channel; Mechanosensitive ion channel
NM_121087.3 → NP_568230.2 MSCS-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568230.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DHF7, F4KGW2, Q56X46, Q9LXA1

UniProtKB/TrEMBL

A0A5S9Y3L1

Conserved Domains (2) summary

COG0668
Location:159 → 476

MscS; Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis]

pfam00924
Location:244 → 436

MS_channel; Mechanosensitive ion channel
NM_001203349.1 → NP_001190278.1 MSCS-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190278.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3L1

Conserved Domains (2) summary

COG0668
Location:157 → 474

MscS; Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis]

pfam00924
Location:242 → 434

MS_channel; Mechanosensitive ion channel