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    APT1 adenine phosphoribosyl transferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839636, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APT1
    Official Full Name
    adenine phosphoribosyl transferase 1
    Primary source
    TAIR:AT1G27450
    Locus tag
    AT1G27450
    See related
    Araport:AT1G27450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenine phosphoribosyl transferase 1; ADENINE PHOSPHORIBOSYL TRANSFERASE 1; ARABIDOPSIS THALIANA ADENINE PHOSPHORIBOSYLTRANSFERASE 1; ATAPT1; F17L21.24; F17L21_24
    Summary
    Adenosine phosphoribosyl transferase(E.C:2.4.2.7), involved in the one-step salvage of adenine to AMP.
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    Genomic context

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    See APT1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (9531809..9534141)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Exostosin family protein Neighboring gene no pollen germination related 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second form of adenine phosphoribosyltransferase in Arabidopsis thaliana with relative specificity towards cytokinins. Schnorr KM, et al. Plant J, 1996 Jun. PMID 8696367
    2. Adenine phosphoribosyl transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis. Zhang X, et al. Mol Plant, 2013 Sep. PMID 23658065
    3. Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism. Allen M, et al. Physiol Plant, 2002 May. PMID 12010467
    4. Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis. Li G, et al. Nat Cell Biol, 2011 May. PMID 21499259
    5. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study defines APT1 as a key metabolic enzyme participating in the cytokinin inactivation by phosphoribosylation.
      Title: Adenine phosphoribosyl transferase 1 is a key enzyme catalyzing cytokinin conversion from nucleobases to nucleotides in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198175.1
    NM_001332762.1
    NM_179383.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables adenine phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenine salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokinin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    adenine phosphoribosyl transferase 1
    NP_001185104.1
    • adenine phosphoribosyl transferase 1 (APT1); CONTAINS InterPro DOMAIN/s: Adenine phosphoribosyl transferase (InterPro:IPR005764), Phosphoribosyltransferase (InterPro:IPR000836); BEST Arabidopsis thaliana protein match is: adenine phosphoribosyl transferase 3 (TAIR:AT4G22570.1).
    NP_564284.1
    • adenine phosphoribosyl transferase 1 (APT1); FUNCTIONS IN: adenine phosphoribosyltransferase activity; INVOLVED IN: response to cadmium ion, adenine salvage; LOCATED IN: cytosol, chloroplast, plasma membrane, plant-type cell wall; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Adenine phosphoribosyl transferase (InterPro:IPR005764), Phosphoribosyltransferase (InterPro:IPR000836); BEST Arabidopsis thaliana protein match is: adenine phosphoribosyl transferase 3 (TAIR:AT4G22570.1); Has 9277 Blast hits to 9277 proteins in 2485 species: Archae - 216; Bacteria - 6424; Metazoa - 180; Fungi - 181; Plants - 165; Viruses - 0; Other Eukaryotes - 2111 (source: NCBI BLink).
    NP_849714.1
    • adenine phosphoribosyl transferase 1 (APT1); FUNCTIONS IN: adenine phosphoribosyltransferase activity; INVOLVED IN: response to cadmium ion, adenine salvage; LOCATED IN: cytosol, chloroplast, plasma membrane, plant-type cell wall; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Adenine phosphoribosyl transferase (InterPro:IPR005764), Phosphoribosyltransferase (InterPro:IPR000836); BEST Arabidopsis thaliana protein match is: adenine phosphoribosyl transferase 3 (TAIR:AT4G22570.1); Has 9362 Blast hits to 9362 proteins in 2524 species: Archae - 217; Bacteria - 6510; Metazoa - 180; Fungi - 181; Plants - 165; Viruses - 0; Other Eukaryotes - 2109 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9531809..9534141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102509.4 → NP_564284.1  adenine phosphoribosyl transferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564284.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31166, Q8LGF6, Q9FZJ0
      UniProtKB/TrEMBL
      A0A178W2H2, A0A178W2J6, A0A5S9W282
      Conserved Domains (1) summary
      PLN02293
      Location:61 → 243
      PLN02293; adenine phosphoribosyltransferase

    2. NM_179383.3 → NP_849714.1  adenine phosphoribosyl transferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DWB6
      Conserved Domains (1) summary
      PLN02293
      Location:1 → 183
      PLN02293; adenine phosphoribosyltransferase

    3. NM_001198175.1 → NP_001185104.1  adenine phosphoribosyl transferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W2H2, F4HSX1
      Conserved Domains (1) summary
      PLN02293
      Location:77 → 284
      PLN02293; adenine phosphoribosyltransferase

    4. NM_001332762.1 → NP_001323015.1  adenine phosphoribosyl transferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DWB6
      Conserved Domains (1) summary
      PLN02293
      Location:1 → 183
      PLN02293; adenine phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31166.2

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