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    FKBP53 FK506 BINDING PROTEIN 53 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828637, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FKBP53
    Official Full Name
    FK506 BINDING PROTEIN 53
    Primary source
    TAIR:AT4G25340
    Locus tag
    AT4G25340
    See related
    Araport:AT4G25340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFKBP53; FK506 BINDING PROTEIN 53; T30C3.20; T30C3_20
    Summary
    Encodes a member of the FKBP-type immunophilin family that functions as a histone chaparone. Binds to 18S rDNA and represses its expression.
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    Genomic context

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    See FKBP53 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Sequence:
    Chromosome: 4; NC_003075.7 (12959349..12962771, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene AT hook motif DNA-binding family protein Neighboring gene SAWADEE protein Neighboring gene EXS (ERD1/XPR1/SYG1) family protein Neighboring gene TRICHOME BIREFRINGENCE-LIKE 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains. Singh AK, et al. Nucleic Acids Res, 2020 Feb 20. PMID 31807785, Free PMC Article
    2. AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis. Li H, et al. Cell Res, 2010 Mar. PMID 20142844
    3. A DEK domain-containing protein modulates chromatin structure and function in Arabidopsis. Waidmann S, et al. Plant Cell, 2014 Nov. PMID 25387881, Free PMC Article
    4. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203907.1
    NM_118666.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FK506 BINDING PROTEIN 53
    NP_001190836.1
    • FK506 BINDING PROTEIN 53 (FKBP53); CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G05420.1).
    NP_567717.1
    • FK506 BINDING PROTEIN 53 (FKBP53); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, histone binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G05420.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12959349..12962771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118666.3 → NP_567717.1  FK506 BINDING PROTEIN 53 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZG9, Q9STK2
      UniProtKB/TrEMBL
      A0A178V311, A0A5S9XVQ0
      Conserved Domains (2) summary
      pfam00254
      Location:384 → 474
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam03066
      Location:3 → 134
      Nucleoplasmin; Nucleoplasmin

    2. NM_001203907.1 → NP_001190836.1  FK506 BINDING PROTEIN 53 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V311, A0A5S9XVQ0, F4JSK5
      Conserved Domains (2) summary
      pfam00254
      Location:384 → 433
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam03066
      Location:3 → 134
      Nucleoplasmin; Nucleoplasmin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZG9.1

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