NCS1 permease, cytosine/purines, uracil, thiamine, allantoin family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: NCS1
Official Full Name: permease, cytosine/purines, uracil, thiamine, allantoin family protein
Primary source: TAIR:AT5G03555
Locus tag: AT5G03555
See related: Araport:AT5G03555
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtNCS1; nucleobase cation symporter 1
Summary: Encodes PLUTO (plastidic nucleobase transporter), a member of the Nucleobase:Cation-Symporter1 protein family, capable of transporting purine and pyrimidine nucleobases.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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These data implicate PLUTO in plastidial transport and salvage of hydroxymethylpyrimidine.
Title: The PLUTO plastidial nucleobase transporter also transports the thiamin precursor hydroxymethylpyrimidine.
molecular determinants for PLUTO substrate binding
Title: Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.
PLUTO (for plastidic nucleobase transporter) was identified as a member of the Nucleobase:Cation-Symporter1 protein family from Arabidopsis thaliana, capable of transporting purine and pyrimidine nucleobases.[PLUTO]
Title: De novo pyrimidine nucleotide synthesis mainly occurs outside of plastids, but a previously undiscovered nucleobase importer provides substrates for the essential salvage pathway in Arabidopsis.
genetic and molecular characterization of AtNCS1
Title: Genetic and molecular characterization reveals a unique nucleobase cation symporter 1 in Arabidopsis.

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NM_120436.4

Function	Evidence Code	Pubs
enables nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within pyrimidine nucleobase salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in plastid envelope	IDA Inferred from Direct Assay more info	PubMed

Preferred Names: permease, cytosine/purines, uracil, thiamine, allantoin family protein

NP_568122.2

permease, cytosine/purines, uracil, thiamine, allantoin family protein; FUNCTIONS IN: nucleobase transmembrane transporter activity; INVOLVED IN: nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Permease, cytosine/purines, uracil, thiamine, allantoin (InterPro:IPR001248); Has 4949 Blast hits to 4943 proteins in 959 species: Archae - 81; Bacteria - 2901; Metazoa - 0; Fungi - 592; Plants - 52; Viruses - 0; Other Eukaryotes - 1323 (source: NCBI BLink).

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