MBF1B multiprotein bridging factor 1B [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MBF1B
Official Full Name: multiprotein bridging factor 1B
Primary source: TAIR:AT3G58680
Locus tag: AT3G58680
See related: Araport:AT3G58680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMBF1B; multiprotein bridging factor 1B; MULTIPROTEIN BRIDGING FACTOR 1B
Summary: One of three genes in A. thaliana encoding multiprotein bridging factor 1, a highly conserved transcriptional coactivator. May serve as a bridging factor between a bZIP factor and TBP. Its expression is developmentally regulated.
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Genomic context

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See MBF1B in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (21707247..21708972)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

triple knock-down mutant for MBF1a, MBF1b andtMBF1c sensitive to oxidative stress and osmotic stress
Title: The analysis of an Arabidopsis triple knock-down mutant reveals functions for MBF1 genes under oxidative stress conditions.
AtMBF1s are involved in both leaf size control through regulation of cell size and regulation of endoreduplication in leaf cells.
Title: Arabidopsis MBF1s control leaf cell cycle and its expansion.
Multiprotein bridging factor 1a (MBF1a) is overexpressed during abiotic and biotic stress tolerance.
Title: Abiotic and biotic stress tolerance in Arabidopsis overexpressing the multiprotein bridging factor 1a (MBF1a) transcriptional coactivator gene.
Multiprotein bridging factor 1 (MBF1) is a transcriptional coactivator that predominantly localize in nucleolus. Its function in plants is controlled on the level of transcriptional induction but not by nuclear translocation. [MBF1]
Title: Transcriptional coactivator MBF1s from Arabidopsis predominantly localize in nucleolus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_115730.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: multiprotein bridging factor 1B

NP_191427.1

multiprotein bridging factor 1B (MBF1B); CONTAINS InterPro DOMAIN/s: Lambda repressor-like, DNA-binding (InterPro:IPR010982), Multiprotein bridging factor 1, N-terminal (InterPro:IPR013729), Helix-turn-helix type 3 (InterPro:IPR001387); BEST Arabidopsis thaliana protein match is: multiprotein bridging factor 1A (TAIR:AT2G42680.1); Has 690 Blast hits to 690 proteins in 262 species: Archae - 53; Bacteria - 10; Metazoa - 194; Fungi - 151; Plants - 135; Viruses - 2; Other Eukaryotes - 145 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21707247..21708972

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115730.4 → NP_191427.1 multiprotein bridging factor 1B [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LXT3

UniProtKB/TrEMBL

A0A178V9J8, A0A5S9XM12

Conserved Domains (2) summary

cl26727
Location:85 → 141

aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]

pfam08523
Location:10 → 77

MBF1; Multiprotein bridging factor 1