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    MET1 methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834975, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MET1
    Official Full Name
    methyltransferase 1
    Primary source
    TAIR:AT5G49160
    Locus tag
    AT5G49160
    See related
    Araport:AT5G49160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DDM2; DECREASED DNA METHYLATION 2; DMT01; DMT1; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 01; DNA METHYLTRANSFERASE 1; MET2; methyltransferase 1; METHYLTRANSFERASE 2; METHYLTRANSFERASE I; METI
    Summary
    Encodes a cytosine methyltransferase MET1. Required for silencing of FWA paternal allele in endosperm. Two lines with RNAi constructs directed against DMT1 have reduced agrobacterium-mediated tumor formation.
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    Genomic context

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    See MET1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (19932114..19938470)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene ncRNA Neighboring gene gamete expressed 2 Neighboring gene uncharacterized protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo DNA methylation activity of methyltransferase 1 (MET1) partially restores body methylation in Arabidopsis thaliana. Zubko E, et al. Plant J, 2012 Sep. PMID 22587613
    2. Demethylation-induced developmental pleiotropy in Arabidopsis. Ronemus MJ, et al. Science, 1996 Aug 2. PMID 8662558
    3. DNA methylation and the promotion of flowering by vernalization. Finnegan EJ, et al. Proc Natl Acad Sci U S A, 1998 May 12. PMID 9576969, Free PMC Article
    4. Temporal and spatial downregulation of Arabidopsis MET1 activity results in global DNA hypomethylation and developmental defects. Kim M, et al. Mol Cells, 2008 Dec 31. PMID 18820427, Free PMC Article
    5. [Is the cytosine DNA methyltransferase gene MET1 regulated by DNA methylation in Arabidopsis thaliana plants?]. Apashkin VV, et al. Genetika, 2011 Mar. PMID 21542302

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MET1-Dependent DNA Methylation Represses Light Signaling and Influences Plant Regeneration in Arabidopsis.
      Title: MET1-Dependent DNA Methylation Represses Light Signaling and Influences Plant Regeneration in Arabidopsis.
    2. The findings reveal that MET1-mediated shoot regeneration is regulated by the cytokinin-induced cell cycle, and provide new insights into the regulation of DNA methylation in shoot regeneration.
      Title: DNA METHYLTRANSFERASE1-mediated shoot regeneration is regulated by cytokinin-induced cell cycle in Arabidopsis.
    3. Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi-alleles
      Title: Induction of epigenetic variation in Arabidopsis by over-expression of DNA METHYLTRANSFERASE1 (MET1).
    4. MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
      Title: A reciprocal inhibition between ARID1 and MET1 in male and female gametes in Arabidopsis.
    5. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
      Title: MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis.
    6. Met1 gene expression throughout normal development, particularly in the flower
      Title: [Developmental expression of Arabidopsis methyltransferase genes MET1, DRM2 and CMT3].
    7. MET1 is a contributor to epigenetic diversity in Arabidopsis.
      Title: Transmission of epi-alleles with MET1-dependent dense methylation in Arabidopsis thaliana.
    8. VIM proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation and histone modification status in collaboration with MET1
      Title: Arabidopsis VIM proteins regulate epigenetic silencing by modulating DNA methylation and histone modification in cooperation with MET1.
    9. VIM proteins function in transcriptional regulation via their roles in the MET1 DNA methylation pathway.
      Title: VIM proteins regulate transcription exclusively through the MET1 cytosine methylation pathway.
    10. Genetic studies indicate that the Polycomb Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
      Title: Genomic imprinting in the Arabidopsis embryo is partly regulated by PRC2.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344823.1
    NM_124293.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA-mediated transformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epigenetic programming in the endosperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression via chromosomal CpG island methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within zygote asymmetric cytokinesis in embryo sac IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase 1
    NP_199727.1
    • methyltransferase 1 (MET1); FUNCTIONS IN: methyltransferase activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA (cytosine-5)-methyltransferase 1 (InterPro:IPR017198), DNA methylase, C-5 cytosine-specific (InterPro:IPR001525), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), DNA methylase, C-5 cytosine-specific, active site (InterPro:IPR018117); BEST Arabidopsis thaliana protein match is: DNA (cytosine-5-)-methyltransferase family protein (TAIR:AT4G08990.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19932114..19938470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124293.4 → NP_199727.1  methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34881, Q0WLP5, Q0WPP9, Q5C994
      UniProtKB/TrEMBL
      A0A178UE49, A0A654G9X6
      Conserved Domains (4) summary
      COG0270
      Location:1095 → 1525
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd04708
      Location:904 → 1105
      BAH_plantDCM_II; BAH, or Bromo Adjacent Homology domain, second copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects ...
      cd04712
      Location:732 → 869
      BAH_DCM_I; BAH, or Bromo Adjacent Homology domain, as present in DNA (Cytosine-5)-methyltransferases (DCM) 1. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the genome. ...
      pfam12047
      Location:79 → 213
      DNMT1-RFD; Cytosine specific DNA methyltransferase replication foci domain

    2. NM_001344823.1 → NP_001331134.1  methyltransferase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCY7, A0A654G9X6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34881.1

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