OASA1 O-acetylserine (thiol) lyase (OAS-TL) isoform A1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: OASA1
Official Full Name: O-acetylserine (thiol) lyase (OAS-TL) isoform A1
Primary source: TAIR:AT4G14880
Locus tag: AT4G14880
See related: Araport:AT4G14880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCYS-3A; CYTACS1; DL3480C; FCAALL.34; O-ACETHYLSERINE SULFHYDRYLASE; O-acetylserine (thiol) lyase (OAS-TL) isoform A1; O-ACETYLSERINE (THIOL)LYASE; OLD3; ONSET OF LEAF DEATH 3
Summary: Encodes a cytosolic isoform of cytosolic O-acetylserine(thiol)lyase, a key enzyme in cysteine biosynthesis and for the fixation of inorganic sulfide. It catalyzes the formation of cysteine from O-acetylserine and inorganic sulfide. Gene expression is predominant in the root cortex and the xylem parenchyma. Gene expression is induced in leave, stems and roots by high salt and heavy metal stresses, mediated by ABA. Lines carrying semi-dominant mutations exhibit early senescence. Required for pollen tube growth and/or fertilization.
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Genomic context

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See OASA1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (8517960..8520596, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in R-mediated innate immunity and disease susceptibility
Title: Activation of R-mediated innate immunity and disease susceptibility is affected by mutations in a cytosolic O-acetylserine (thiol) lyase in Arabidopsis.
Subcellular localization of OAS-TL proteins is more important for efficient Cysteine synthesis than total cellular OAS-TL activity in leaves.
Title: Successful fertilization requires the presence of at least one major O-acetylserine(thiol)lyase for cysteine synthesis in pollen of Arabidopsis.
The old3-1 mutation causes genome-dependent and independent phenotypes and uncovers a novel function for the mutated OAS-TL in cell death regulation.
Title: A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis.
Null alleles of oastlA or oastlB alone showed that cytosolic OAS-TL A and plastid OAS-TL B were completely dispensable, although together they contributed 95% of total OAS-TL activity. oastlC plants also showed retarded growth.
Title: Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.
O-acetylserine sulfhydrylase catalyzes the final step of cysteine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-acetylserine into cysteine. [O-Acetylserine sulfhydrylase ] [AtOASS]
Title: Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203803.1

Supported by ESTs:

NM_001203804.1

Supported by ESTs:

NM_001340975.1

Supported by ESTs:

NM_117574.4

Supported by ESTs:

NM_179055.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cysteine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cysteine biosynthetic process from serine	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within double fertilization forming a zygote and endosperm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in peroxisome	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: O-acetylserine (thiol) lyase (OAS-TL) isoform A1

NP_001190732.1

O-acetylserine (thiol) lyase (OAS-TL) isoform A1 (OASA1); CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase (OAS-TL) isoform A2 (TAIR:AT3G22460.1).

NP_001190733.1

O-acetylserine (thiol) lyase (OAS-TL) isoform A1 (OASA1); CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase (OAS-TL) isoform A2 (TAIR:AT3G22460.1).

NP_193224.1

O-acetylserine (thiol) lyase (OAS-TL) isoform A1 (OASA1); FUNCTIONS IN: protein binding, cysteine synthase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 7 components; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase (OAS-TL) isoform A2 (TAIR:AT3G22460.1); Has 20496 Blast hits to 20479 proteins in 2663 species: Archae - 403; Bacteria - 14284; Metazoa - 350; Fungi - 659; Plants - 549; Viruses - 2; Other Eukaryotes - 4249 (source: NCBI BLink).

NP_849386.1

O-acetylserine (thiol) lyase (OAS-TL) isoform A1 (OASA1); FUNCTIONS IN: protein binding, cysteine synthase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 7 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: O-acetylserine (thiol) lyase (OAS-TL) isoform A2 (TAIR:AT3G22460.1); Has 20496 Blast hits to 20479 proteins in 2663 species: Archae - 403; Bacteria - 14284; Metazoa - 350; Fungi - 659; Plants - 549; Viruses - 2; Other Eukaryotes - 4249 (source: NCBI BLink).