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    SMT1 sterol methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831216, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SMT1
    Official Full Name
    sterol methyltransferase 1
    Primary source
    TAIR:AT5G13710
    Locus tag
    AT5G13710
    See related
    Araport:AT5G13710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CEPHALOPOD; CPH; MSH12.18; MSH12_18; SAM:CYCLOARTENOL-C24-METHYLTRANSFERASE; sterol methyltransferase 1
    Summary
    SMT1 controls the level of cholesterol in plants
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    Genomic context

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    See SMT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (4423555..4427324, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene IKI3 family protein Neighboring gene alpha-N-acetylglucosaminidase family / NAGLU family Neighboring gene polyamine oxidase 1 Neighboring gene Uncharacterized protein family (UPF0114) Neighboring gene sigma factor 4 Neighboring gene zinc induced facilitator 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterol methyltransferase 1 controls the level of cholesterol in plants. Diener AC, et al. Plant Cell, 2000 Jun. PMID 10852933, Free PMC Article
    2. The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. Carland F, et al. Plant Physiol, 2010 Jun. PMID 20421456, Free PMC Article
    3. Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes. Cheng Z, et al. Plant Cell, 2003 Oct. PMID 14508009, Free PMC Article
    4. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutants deficient in both SMT1 and SMT2 are embryo lethal.
      Title: The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085110.1
    NM_121374.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables sterol 24-C-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol 24-C-methyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    sterol methyltransferase 1
    NP_001078579.1
    • sterol methyltransferase 1 (SMT1); CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 3 (TAIR:AT1G76090.1); Has 12253 Blast hits to 12250 proteins in 2286 species: Archae - 352; Bacteria - 8578; Metazoa - 91; Fungi - 457; Plants - 727; Viruses - 0; Other Eukaryotes - 2048 (source: NCBI BLink).
    NP_196875.1
    • sterol methyltransferase 1 (SMT1); FUNCTIONS IN: sterol 24-C-methyltransferase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 3 (TAIR:AT1G76090.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4423555..4427324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121374.4 → NP_196875.1  sterol methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LKW1, Q9LM02
      UniProtKB/TrEMBL
      A0A5S9Y3U9, A0A654G0T6
      Conserved Domains (2) summary
      pfam08241
      Location:99 → 192
      Methyltransf_11; Methyltransferase domain
      pfam08498
      Location:271 → 335
      Sterol_MT_C; Sterol methyltransferase C-terminal

    2. NM_001085110.1 → NP_001078579.1  sterol methyltransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LKW1, Q9LM02
      UniProtKB/TrEMBL
      A0A5S9Y3U9, A0A654G0T6
      Conserved Domains (2) summary
      pfam08241
      Location:99 → 192
      Methyltransf_11; Methyltransferase domain
      pfam08498
      Location:271 → 335
      Sterol_MT_C; Sterol methyltransferase C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LM02.1

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