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    MPK18 mitogen-activated protein kinase 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841786, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MPK18
    Official Full Name
    mitogen-activated protein kinase 18
    Primary source
    TAIR:AT1G53510
    Locus tag
    AT1G53510
    See related
    Araport:AT1G53510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MAP KINASE 18; ATMPK18; F22G10.12; mitogen-activated protein kinase 18
    Summary
    member of MAP Kinase
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    Genomic context

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    See MPK18 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (19970334..19974393, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mto 1 responding down 1 Neighboring gene RING/U-box superfamily protein Neighboring gene ncRNA Neighboring gene NAD-dependent epimerase/dehydratase family protein Neighboring gene Chalcone-flavanone isomerase family protein Neighboring gene Peptidase S24/S26A/S26B/S26C family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) Acts Upstream of MKK3 and MPK18 in Two Separate Signaling Pathways Involved in Root Microtubule Functions. Benhamman R, et al. Front Plant Sci, 2017. PMID 28848569, Free PMC Article
    2. Arabidopsis mitogen-activated protein kinase MPK18 mediates cortical microtubule functions in plant cells. Walia A, et al. Plant J, 2009 Aug. PMID 19392697
    3. Mapping out the roles of MAP kinases in plant defense. Innes RW. Trends Plant Sci, 2001 Sep. PMID 11544109
    4. Mitogen-activated protein kinase cascades in plants: a new nomenclature. MAPK Group. Trends Plant Sci, 2002 Jul. PMID 12119167
    5. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPK18 specifically interacts with PHS1 and helps to mediate cortical microtubule functions in plant cells. [MPK18]
      Title: Arabidopsis mitogen-activated protein kinase MPK18 mediates cortical microtubule functions in plant cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104229.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 18
    NP_175756.2
    • mitogen-activated protein kinase 18 (MPK18); CONTAINS InterPro DOMAIN/s: MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: MAP kinase 19 (TAIR:AT3G14720.1); Has 121070 Blast hits to 119835 proteins in 4221 species: Archae - 114; Bacteria - 13840; Metazoa - 44615; Fungi - 12415; Plants - 29396; Viruses - 569; Other Eukaryotes - 20121 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19970334..19974393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104229.4 → NP_175756.2  mitogen-activated protein kinase 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175756.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5C0, Q9LPG7
      UniProtKB/TrEMBL
      A0A5S9WRH3, A0A654ETW3, A0A7G2E0J5
      Conserved Domains (1) summary
      cd07859
      Location:24 → 361
      STKc_TDY_MAPK; Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5C0.4

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