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    IAR4 thiamine diphosphate-binding fold (THDP-binding) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839031, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IAR4
    Official Full Name
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    Primary source
    TAIR:AT1G24180
    Locus tag
    AT1G24180
    See related
    Araport:AT1G24180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3I6.11; F3I6_11; IAA-CONJUGATE-RESISTANT 4
    Summary
    Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900. Serine 296 phosphorylation of IAR4 has critical function in root hair formation and root development. Changing Ser296 in IAR4 to Ala resulted in a phenotype intermediate between mutant and wild-type, while substitution to Asp was either lethal or caused an extreme dwarf phenotype.
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    Genomic context

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    See IAR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (8560420..8563502, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Interleukin-1 receptor-associated kinase 4 protein Neighboring gene triadin Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene SIN3-like 3 Neighboring gene Paired amphipathic helix (PAH2) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. Quint M, et al. Plant Physiol, 2009 Jun. PMID 19395411, Free PMC Article
    2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    4. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
    5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The auxin phenotypes of iar4 mutants are the result of altered indole-3-acetic acid homeostasis.
      Title: Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102264.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion binding HDA PubMed 
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    NP_173828.1
    • IAA-CONJUGATE-RESISTANT 4 (IAR4); FUNCTIONS IN: cobalt ion binding, pyruvate dehydrogenase (acetyl-transferring) activity, zinc ion binding; INVOLVED IN: response to salt stress, metabolic process; LOCATED IN: cytosol, mitochondrion, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: pyruvate dehydrogenase complex E1 alpha subunit (TAIR:AT1G59900.1); Has 9959 Blast hits to 9956 proteins in 1842 species: Archae - 124; Bacteria - 6117; Metazoa - 560; Fungi - 255; Plants - 209; Viruses - 0; Other Eukaryotes - 2694 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8560420..8563502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102264.5 → NP_173828.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48685, Q8H1Y0
      UniProtKB/TrEMBL
      A0A178WAC1, A0A5S9VTJ7
      Conserved Domains (1) summary
      PLN02269
      Location:32 → 393
      PLN02269; Pyruvate dehydrogenase E1 component subunit alpha
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1Y0.2

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