REV Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: REV
Official Full Name: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
Primary source: TAIR:AT5G60690
Locus tag: AT5G60690
See related: Araport:AT5G60690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: HOMEODOMAIN-LEUCINE ZIPPER PROTEIN; HOMEODOMAIN-LEUCINE ZIPPER PROTEIN IFL1; IFL; IFL1; INTERFASCICULAR FIBERLESS; INTERFASCICULAR FIBERLESS 1; MUP24.16; MUP24_16; REVOLUTA
Summary: REVOLUTA regulates meristem initiation at lateral positions. a member of a small homeodomain-leucine zipper family. Has overlapping functions with PHAVOLUTA and PHABULOSA.
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Genomic context

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See REV in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 18

Sequence:: Chromosome: 5; NC_003076.8 (24396981..24402195)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Non-JAZ TIFY Protein TIFY8 of Arabidopsis thaliana Interacts with the HD-ZIP III Transcription Factor REVOLUTA and Regulates Leaf Senescence.
Title: The Non-JAZ TIFY Protein TIFY8 of Arabidopsis thaliana Interacts with the HD-ZIP III Transcription Factor REVOLUTA and Regulates Leaf Senescence.
Multi-level analysis of the interactions between REVOLUTA and MORE AXILLARY BRANCHES 2 in controlling plant development reveals parallel, independent and antagonistic functions.
Title: Multi-level analysis of the interactions between REVOLUTA and MORE AXILLARY BRANCHES 2 in controlling plant development reveals parallel, independent and antagonistic functions.
characterization of the cell type specific expression patterns of auxin responsive genes and identify a set of genes involved in organogenesis repressed by both REV and KAN1
Title: An integrated analysis of cell-type specific gene expression reveals genes regulated by REVOLUTA and KANADI1 in the Arabidopsis shoot apical meristem.
BLH6 and KNAT7 bind to the REV promoter and repress REV expression.
Title: BEL1-LIKE HOMEODOMAIN6 and KNOTTED ARABIDOPSIS THALIANA7 interact and regulate secondary cell wall formation via repression of REVOLUTA.
HD-ZIPIII and KANADI regulate tissue-specific transcription factors involved in subsidiary developmental decisions, nearly all major hormone pathways, and new actors (such as indeterminate domain4) in the ad/abaxial regulatory network.
Title: Establishing a framework for the Ad/abaxial regulatory network of Arabidopsis: ascertaining targets of class III homeodomain leucine zipper and KANADI regulation.
REV acts as a redox-sensitive transcription factor, and directly and positively regulates the expression of WRKY53, a master regulator of age-induced leaf senescence.
Title: REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis.
REV acts upstream of auxin biosynthesis and affects directly the expression of several class II HD-ZIP transcription factors that have been shown to act in the shade-avoidance response pathway.
Title: Genome-wide binding-site analysis of REVOLUTA reveals a link between leaf patterning and light-mediated growth responses.
MEKHLA is a negative regulatory domain that prevents dimerization of REV.
Title: A per-ARNT-sim-like sensor domain uniquely regulates the activity of the homeodomain leucine zipper transcription factor REVOLUTA in Arabidopsis.
26S proteasome RPN2a gene and the REVOLUTA regulated inflorescence and floral meristem functions.
Title: Convergence of the 26S proteasome and the REVOLUTA pathways in regulating inflorescence and floral meristem functions in Arabidopsis.
Dof5.1 protein regulates leaf adaxial-abaxial polarity by controlling REV expression.
Title: The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_125462.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of bilateral symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meristem initiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polarity specification of adaxial/abaxial axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of adaxial/abaxial axis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem and phloem pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein

NP_200877.1

REVOLUTA (REV); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT2G34710.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24396981..24402195

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125462.4 → NP_200877.1 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200877.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5YZA2, A5YZA3, A5YZA4, A5YZA7, A5YZC3, Q9M5B6, Q9SE43

UniProtKB/TrEMBL

A0A178UL04, A0A654GCU6

Conserved Domains (4) summary

cd08875
Location:155 → 371

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

cd14686
Location:77 → 116

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam00046
Location:25 → 83

Homeobox; Homeobox domain

pfam08670
Location:695 → 841

MEKHLA; MEKHLA domain