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    Atp5f1c ATP synthase F1 subunit gamma [ Mus musculus (house mouse) ]

    Gene ID: 11949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5f1cprovided by MGI
    Official Full Name
    ATP synthase F1 subunit gammaprovided by MGI
    Primary source
    MGI:MGI:1261437
    See related
    Ensembl:ENSMUSG00000025781 AllianceGenome:MGI:1261437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5c1; 1700094F02Rik
    Summary
    Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 316.7), kidney adult (RPKM 177.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5f1c in Genome Data Viewer
    Location:
    2 A1; 2 6.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10060841..10085321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10056030..10080510, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31290 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene predicted gene, 54137 Neighboring gene STARR-positive B cell enhancer ABC_E11119 Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA. Ichida M, et al. J Biol Chem, 1998 Apr 3. PMID 9525963
    2. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, et al. Nat Commun, 2020 Sep 24. PMID 32973183, Free PMC Article
    3. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
    4. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. Brody MJ, et al. PLoS One, 2012. PMID 23236519, Free PMC Article
    5. Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Sano M, et al. Cell Metab, 2007 Feb. PMID 17276355

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit gamma, mitochondrial
    Names
    ATP synthase gamma-subunit gene encoding a mitochondrial protein
    ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
    F-ATPase gamma subunit
    F1 gamma
    NP_001106209.1
    NP_001361570.1
    NP_065640.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112738.1 → NP_001106209.1  ATP synthase subunit gamma, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001106209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK158675, BC055785
      Consensus CDS
      CCDS50497.1
      UniProtKB/TrEMBL
      Q8C2Q8, Q9D9D7, Q9ERA8
      Related
      ENSMUSP00000110546.2, ENSMUST00000114896.8
      Conserved Domains (1) summary
      TIGR01146
      Location:2 → 273
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    2. NM_001374641.1 → NP_001361570.1  ATP synthase subunit gamma, mitochondrial isoform c

      Status: VALIDATED

      Source sequence(s)
      AL772367
      Consensus CDS
      CCDS89426.1
      UniProtKB/TrEMBL
      A2AKU9, Q9D9D7, Q9ERA8
      Related
      ENSMUSP00000026887.8, ENSMUST00000026887.14
      Conserved Domains (1) summary
      TIGR01146
      Location:26 → 297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    3. NM_020615.4 → NP_065640.2  ATP synthase subunit gamma, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_065640.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform a).
      Source sequence(s)
      AK158675, BC055785
      Consensus CDS
      CCDS38045.1
      UniProtKB/Swiss-Prot
      Q91VR2
      UniProtKB/TrEMBL
      Q3UD06, Q9D9D7, Q9ERA8
      Related
      ENSMUSP00000110547.3, ENSMUST00000114897.9
      Conserved Domains (1) summary
      TIGR01146
      Location:26 → 297
      ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      10060841..10085321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VR2.1 GenPept UniProtKB/Swiss-Prot:Q91VR2

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