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    TJP1 tight junction protein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 720550, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TJP1provided by VGNC
    Official Full Name
    tight junction protein 1provided by VGNC
    Primary source
    VGNC:VGNC:78360
    See related
    Ensembl:ENSMMUG00000017878
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TJP1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (7536941..7809930)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (6314588..6587506, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene putative GED domain-containing protein DNM1P34 Neighboring gene golgin subfamily A member 8S-like Neighboring gene uncharacterized LOC106999103 Neighboring gene uncharacterized LOC114679352 Neighboring gene endosomal transmembrane epsin interactor 2 Neighboring gene small nucleolar RNA SNORA32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-1
    Names
    tight junction protein 1 (zona occludens 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      7536941..7809930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028850671.1 → XP_028706504.1  tight junction protein ZO-1 isoform X1

      UniProtKB/TrEMBL
      F6V6C5
      Conserved Domains (8) summary
      PHA03377
      Location:988 → 1395
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1269 → 1745
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1785 → 1884
      ZU5; ZU5 domain

    2. XM_028850672.1 → XP_028706505.1  tight junction protein ZO-1 isoform X2

      UniProtKB/TrEMBL
      F6V6C5
      Conserved Domains (8) summary
      PHA03377
      Location:988 → 1395
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1269 → 1745
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1785 → 1874
      ZU5; ZU5 domain

    3. XM_028850674.1 → XP_028706507.1  tight junction protein ZO-1 isoform X4

      UniProtKB/TrEMBL
      G7MW84
      Conserved Domains (8) summary
      smart00218
      Location:1782 → 1888
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03377
      Location:988 → 1395
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1269 → 1745
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)

    4. XM_028850673.1 → XP_028706506.1  tight junction protein ZO-1 isoform X3

      UniProtKB/TrEMBL
      G7MW84
      Conserved Domains (8) summary
      PHA03377
      Location:988 → 1395
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1269 → 1728
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1768 → 1867
      ZU5; ZU5 domain

    5. XM_028850675.1 → XP_028706508.1  tight junction protein ZO-1 isoform X5

      UniProtKB/TrEMBL
      G7MW84
      Conserved Domains (8) summary
      smart00218
      Location:1765 → 1871
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03377
      Location:988 → 1395
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1269 → 1728
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)

    6. XM_028850677.1 → XP_028706510.1  tight junction protein ZO-1 isoform X10

      UniProtKB/TrEMBL
      A0A5K1UF47
      Conserved Domains (7) summary
      PTZ00449
      Location:1014 → 1440
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1705 → 1804
      ZU5; ZU5 domain

    7. XM_028850680.1 → XP_028706513.1  tight junction protein ZO-1 isoform X13

      UniProtKB/TrEMBL
      A0A5K1UF47
      Conserved Domains (7) summary
      cd12026
      Location:651 → 715
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:749 → 928
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1189 → 1648
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:559 → 635
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1688 → 1787
      ZU5; ZU5 domain

    8. XM_015141744.2 → XP_014997230.2  tight junction protein ZO-1 isoform X6

      UniProtKB/TrEMBL
      F6V6C5
      Conserved Domains (8) summary
      PHA03377
      Location:947 → 1354
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1228 → 1704
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1744 → 1843
      ZU5; ZU5 domain

    9. XM_028850676.1 → XP_028706509.1  tight junction protein ZO-1 isoform X8

      UniProtKB/TrEMBL
      G7MW84
      Conserved Domains (8) summary
      PHA03377
      Location:947 → 1354
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1228 → 1687
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1728 → 1816
      ZU5; ZU5 domain

    10. XM_015141752.2 → XP_014997238.2  tight junction protein ZO-1 isoform X14

      UniProtKB/TrEMBL
      A0A5K1UF47
      Conserved Domains (7) summary
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1148 → 1607
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1647 → 1746
      ZU5; ZU5 domain

    11. XM_015141753.2 → XP_014997239.2  tight junction protein ZO-1 isoform X15

      UniProtKB/TrEMBL
      H9FZ34
      Conserved Domains (7) summary
      smart00218
      Location:1644 → 1750
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1148 → 1607
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)

    12. XM_015141748.2 → XP_014997234.2  tight junction protein ZO-1 isoform X9

      UniProtKB/TrEMBL
      G7MW84
      Conserved Domains (8) summary
      smart00218
      Location:1724 → 1830
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03377
      Location:947 → 1354
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1228 → 1687
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)

    13. XM_015141746.2 → XP_014997232.2  tight junction protein ZO-1 isoform X7

      UniProtKB/TrEMBL
      F7F5R3, G7MW84
      Related
      ENSMMUP00000023502.4, ENSMMUT00000025122.4
      Conserved Domains (8) summary
      PHA03377
      Location:947 → 1354
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:610 → 674
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:708 → 887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:276 → 356
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1228 → 1687
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:115 → 200
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:518 → 594
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1727 → 1826
      ZU5; ZU5 domain

    14. XM_028850678.1 → XP_028706511.1  tight junction protein ZO-1 isoform X11

      UniProtKB/TrEMBL
      F6V6C5
      Related
      ENSMMUP00000047654.2, ENSMMUT00000065684.2
      Conserved Domains (8) summary
      PHA03377
      Location:895 → 1302
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:558 → 622
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:656 → 835
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183 → 263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1176 → 1652
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:22 → 107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:466 → 542
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1692 → 1791
      ZU5; ZU5 domain

    15. XM_015141754.2 → XP_014997240.1  tight junction protein ZO-1 isoform X16

      UniProtKB/TrEMBL
      F6V6E6, G7MW84, H9FZ35
      Related
      ENSMMUP00000033964.3, ENSMMUT00000040935.3
      Conserved Domains (8) summary
      smart00218
      Location:1631 → 1737
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03377
      Location:854 → 1261
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:517 → 581
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:615 → 794
      GuKc; Guanylate kinase homologues
      smart00228
      Location:183 → 263
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1135 → 1594
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:22 → 107
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:425 → 501
      PDZ; PDZ domain (Also known as DHR or GLGF)

    16. XM_028850679.1 → XP_028706512.1  tight junction protein ZO-1 isoform X12

      UniProtKB/TrEMBL
      F6V6C5
      Conserved Domains (8) summary
      PHA03377
      Location:893 → 1300
      PHA03377; EBNA-3C; Provisional
      cd12026
      Location:556 → 620
      SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
      smart00072
      Location:654 → 833
      GuKc; Guanylate kinase homologues
      smart00228
      Location:181 → 261
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK10263
      Location:1174 → 1650
      PRK10263; DNA translocase FtsK; Provisional
      cd00992
      Location:20 → 105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:464 → 540
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam00791
      Location:1690 → 1789
      ZU5; ZU5 domain
    Nucleotide Protein
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